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ProteomicsSPPL3 cleavage of glycosyltransferases regulates their activity
The GxGD intramembrane-cleaving aspartylprotease signal peptide peptidase-like 3 (SPPL3) is a Golgi-resident, multi-pass membrane protein that is highly conserved among multicellular eukaryotes pointing to a pivotal physiological function in the Golgi network. Recently, the key branching enzyme N-ac...
ORGANISM(S): Homo sapiens (Human) 
2015-05-08 | PXD001672 | Pride
Substrates Protease Specs Sppl3 
ProteomicsTumor-expressed SPPL3 supports innate anti-tumor immune responses
The development of an effective anti-tumor response relies on the synergistic actions of various immune cells that recognize tumor cells via distinct receptors. Tumors, however, often manipulate receptor-ligand interactions to evade recognition by the immune system. Recently, we highlighted the role...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD056501 | Pride
Sppl3 Cd8 t-cells Anti-tumor response B3gnt5 
ProteomicsN-terminome analyses of the intramembrane-cleaving protease SPPL3
The intramembrane protease SPPL3 can specifically cleave select Golgi enzymes, enabling their secretion and concomitantly altering global cellular glycosylation, yet the entire range of Golgi glycan-modifying enzymes cleaved by SPPL3 under physiological conditions remains to be defined. Here, we est...
ORGANISM(S): Homo sapiens (Human) 
2022-03-17 | PXD028769 | Pride
Hek293 Label-free Hela Sppl3 N-terminomics 
UnknownSecretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways.
Not available
S-EPMC4458722 | biostudies-literature
UnknownTumor-Expressed SPPL3 Supports Innate Antitumor Immune Responses.
Not available
S-EPMC11830388 | biostudies-literature
UnknownA protease-independent function for SPPL3 in NFAT activation.
Not available
S-EPMC4272424 | biostudies-literature
UnknownHelical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage.
Not available
S-EPMC9722940 | biostudies-literature
UnknownNK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3.
Not available
S-EPMC4779696 | biostudies-literature
ProteomicsGlycosylation landscape of CAR-T in AAVS1 and SPPL3 knockout
In this study, we delved into deciphering the glycosylation patterns and precise localization of glycosylation sites within CAR-T proteins. Specifically, we focused on samples derived from human T cells that underwent gene knockout of AAVS1 and SPPL3, two critical genes that could potentially influe...
ORGANISM(S): Homo sapiens (Human) 
2025-05-23 | PXD052748 | Pride
Car-t Sppl3 Aavs1 Glycosylation Lc-ms/ms 
UnknownShedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation.
Not available
S-EPMC4282638 | biostudies-literature
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