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ProteomicsThe cyclin dependent kinase inhibitor Roscovitine reverses diet-induced metabolic disruption in obese mice
We show that roscovitine; a cyclin-dependent kinases inhibitor; given to mice during the last six weeks of a 19-week high fat diet, reduced weight gain and prevented accompanying insulin resistance, hepatic steatosis, visceral adipose tissue (eWAT) inflammation and fibrosis. It also restored insulin...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD027981 | Pride
Proteomics Obesity Adipose mitochondria Therapy Roscovitine 
ProteomicsProteomic and phosphoproteomic profiling of SFTPCI73T expressing patient-specific pluripotent stem cell-derived alveolar epithelial type 2 cells and their gene-edited corrected counterparts.
We performed proteomic and phosphoproteomic profiling of cells derived from human induced pluripotent stem cells (iPSCs) using our previously described distal lung directed differentiation protocol to generate alveolar epithelial type 2 cells (iAEC2s). We used the SPC2 human iPSC line and specifical...
ORGANISM(S): Homo sapiens (Human) 
2021-10-07 | PXD022334 | Pride
Autophagy Proteomics Pluripotent stem cells Pulmonary fibrosis Alveolar epithelial type 2 cells 
ProteomicsProteomic and phosphoproteomic profiling in heart failure with preserved ejection fraction (HFpEF)
Although the prevalence of heart failure with preserved ejection fraction (HFpEF) is increasing, evidence-based therapies for HFpEF are rare, likely due to an incomplete understanding of this disease. This study sought to identify the cardiac-specific features of protein and phosphoprotein in a muri...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-15 | PXD033501 | Pride
Metabolism Proteomics Sirt3 Mitochondria Hfpef Titin Phosphoproteomics 
ProteomicsPhosphoproteomic Survey of Human iPSC-derived Lung Alveolar Type 2 Cells Reveals Cytopathogenic Host Responses to SARS-CoV-2 Infection
Human transmission of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the causative pathogen of the coronavirus disease 2019 (COVID-19) pandemic, is exerting a massive health and socioeconomic burden. The virus infects pneumocytes, also known as alveolar epithelial type 2 (AT2) cells, ...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 
2020-11-20 | PXD020183 | Pride
Sars-cov-2 Mass spectrometry Human alveolar cells Drug targets Infection Phosphoproteomics Covid-19 Signaling Host pathways Pathogenesis Lung organoids 
ProteomicsUpregulation of USP18-ISG15 axis associates with protective immune responses and limited histopathology during SARS-CoV2 infection of the human lung
Investigating the intra-lung human immune responses to SARS-CoV-2, and how immune signatures temporally correlate to distinct histopathological manifestations of disease in the human lung, is not possible in human patients. While current non-human primate and rodent models have proven instrumental f...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-04-14 | PXD025851 | Pride
Lung fetal xenograft Humanized mice Sars-cov-2 Covid19 
ProteomicsBlubber proteome response to repeated ACTH administration in juvenile elephant seals
Proteins were isolated from the inner blubber layer (closest to muscle) of juvenile elephant seals undergoing a repeated ACTH administration experiment (for details, see McCormley et al., 2018, doi: 10.1093/conphys/coy040; Deyarmin et al., 2019, doi:10.1038/s41598-019-39089-2). Sample preparation wa...
ORGANISM(S): Mirounga Angustirostris (ncbitaxon:9716) 
2019-07-29 | MSV000084153 | MassIVE
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