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MetabolomicsIdentification of metabolites of trifunctional sphingomyelin (TFSM1) in HeLa 229 cells infected with Chlamydia trachomatis

Chlamydia trachomatis is an obligate intracellular bacterial pathogen and a leading cause of sexually transmitted infections worldwide. During its biphasic developmental cycle, infectious, non-replicative elementary bodies alternate with replicative reticulate bodies within a membrane-bound intra...

2026-08-10 | MTBLS15303 | MetaboLights
TranscriptomicsHost cell responses to persistent mycoplasmas--different stages in infection of HeLa cells with Mycoplasma hominis
M. hominis adherence, colonisation and invasion of HeLa cells were characterised in a time-course study using microarray-based analysis of the HeLa cell transcriptome: 0 h to monitor the baseline of transcription, 4 h to examine host reactions to mycoplasma attachment, 48 h to capture in addition th...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-54698 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profile in Newcastle disease virus-infected HeLa cells
Three small RNA libraries constructed from uninfected HeLa cells or the cells infected with NDV strain Herts/33 at 6 and 12 hr post inoculation were sequenced using an Illumina platform.Three replicates of each group (Mock, NDV-6h and NDV-12h) were prepared and pooled separately for library construc...
ORGANISM(S): Homo sapiens 
2020-11-08 | E-MTAB-9690 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of HeLa cells after immunoprecipitation of U2AF65 associated mRNAs
U2AF65 is an essential splicing factor involved in the 3'splice site recognition dureing the first steps of spliceosome assembly. In addition, this protein has nucleocytoplasmic shuttling activity and the Drosophila homologue has been implicated in mRNA export. We have used microarray hybridization ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6022 | biostudies-arrayexpress
GenomicsWhole Cell Extract
Most human genes are loaded with promoter proximally paused RNA polymerase II (RNAP II) molecules that are poised for release into productive elongation by P-TEFb. Gdown1, a protein that renders RNAP II responsive to mediator, is involved in RNAP II elongation control. During in vitro transcription ...
ORGANISM(S): Homo sapiens 
2012-02-21 | E-GEOD-35882 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation profiling of human HeLa cells after immunoprecipitation of ptb65 associated mRNAs
PTB is multifunctional RNA binding protein reported to be involved in splicing, 3' -end processing, stability and translational regulation. Sample preparation methods (Gama-Carvalho et al, 2006, submitted); Suspension HeLa cells were grown in DMEM, 10% FCS, Pen/Strep and split 1:2 the day before har...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6021 | biostudies-arrayexpress
TranscriptomicsLocalization profiling of mRNAs associated with microtubules and microtubule bound polysomes in human HeLa cells and unfertilized Xenopus eggs demonstrates conserved localization of mRNAs to mitotic microtubules
Microtubules were purified from mitotic Xenopus or Hela extracts and associated mRNAs were compared to total extract.
ORGANISM(S): Homo sapiens 
2007-12-31 | E-MEXP-1320 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of dexamethasone treated substrates in HeLa cell
Analysis of dexamethasone treated substrates during 3 hr in HeLa cell. Total RNA obtained from HeLa cells with treatement of dexamethasone during 3hr. The up- or down-regulated transcripts were compare to control (DMSO) treated HeLa cell RNA extract. Significant transcripts were confirmed by replica...
ORGANISM(S): Homo sapiens 
2015-02-22 | E-GEOD-49591 | biostudies-arrayexpress
TranscriptomicsTIA proteins drives global and specific translational repression of genes linked to the cell-cycle progression and DNA replication/repair
The reduction of T-cell intracellular antigen (TIA) proteins in transformed cells leads to the acquisition of aberrant cellular phenotypes promoting uncontrolled cell proliferation and tumor growth. Here we show that global and specific translational rates are regulatory gene events that contribute ...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-54540 | biostudies-arrayexpress
TranscriptomicsGene expression data following Cyclin T2 and Cyclin T1 depletion by shRNA in HeLa cells
We have characterized gene expression changes in HeLa cells following long term depletion of Cyclin T2 or Cyclin T1 using shRNA HeLa cells were transduced with VSV-G pseudotyped lentiviral vectors expressing shRNA against either Cyclin T2 or Cyclin T1. As a control, cells were transduced with shRNA...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-28339 | biostudies-arrayexpress
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