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MetabolomicsIdentification of metabolites of trifunctional sphingomyelin (TFSM1) in HeLa 229 cells infected with Chlamydia trachomatis

Chlamydia trachomatis is an obligate intracellular bacterial pathogen and a leading cause of sexually transmitted infections worldwide. During its biphasic developmental cycle, infectious, non-replicative elementary bodies alternate with replicative reticulate bodies within a membrane-bound intra...

2026-08-10 | MTBLS15303 | MetaboLights
MetabolomicsShotgun lipidomics of HeLa whole-cell lysates and lysosomes following LLOMe treatment

Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...

2026-07-03 | MTBLS14737 | MetaboLights
TranscriptomicsHost cell responses to persistent mycoplasmas--different stages in infection of HeLa cells with Mycoplasma hominis
M. hominis adherence, colonisation and invasion of HeLa cells were characterised in a time-course study using microarray-based analysis of the HeLa cell transcriptome: 0 h to monitor the baseline of transcription, 4 h to examine host reactions to mycoplasma attachment, 48 h to capture in addition th...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-54698 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profile in Newcastle disease virus-infected HeLa cells
Three small RNA libraries constructed from uninfected HeLa cells or the cells infected with NDV strain Herts/33 at 6 and 12 hr post inoculation were sequenced using an Illumina platform.Three replicates of each group (Mock, NDV-6h and NDV-12h) were prepared and pooled separately for library construc...
ORGANISM(S): Homo sapiens 
2020-11-08 | E-MTAB-9690 | biostudies-arrayexpress
TranscriptomicsHeLa cells treated with V-ATPase inhibitors or with desoxyferramine compared to HeLa in DMSO or medium with low LDL
Expression data from HeLa cells treated with V-ATPase inhibitors or with desoxyferramine compared to HeLa treated with DMSO or medium with low LDL To determine which genes respond first to low concentrations of V-ATPase inhibition, we treated HeLa cells with two different V-ATPase inhibitors, bafil...
ORGANISM(S): Homo sapiens 
2010-07-22 | E-GEOD-16870 | biostudies-arrayexpress
TranscriptomicsTIA proteins drives global and specific translational repression of genes linked to the cell-cycle progression and DNA replication/repair
The reduction of T-cell intracellular antigen (TIA) proteins in transformed cells leads to the acquisition of aberrant cellular phenotypes promoting uncontrolled cell proliferation and tumor growth. Here we show that global and specific translational rates are regulatory gene events that contribute ...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-54540 | biostudies-arrayexpress
TranscriptomicsExpression data from Bovine leukemia virus (BLV) Tax-transfected HeLa cells
Bovine leukemia virus (BLV) Tax is a transcriptional activator of viral replication and a key contributor to oncogenic potential. We previously identified interesting mutant forms of Tax with elevated (TaxD247G) or reduced (TaxS240P) transactivation effects on BLV replication and propagation. In th...
ORGANISM(S): Homo sapiens 
2013-01-03 | E-GEOD-35823 | biostudies-arrayexpress
TranscriptomicsGene expression data following Cyclin T2 and Cyclin T1 depletion by shRNA in HeLa cells
We have characterized gene expression changes in HeLa cells following long term depletion of Cyclin T2 or Cyclin T1 using shRNA HeLa cells were transduced with VSV-G pseudotyped lentiviral vectors expressing shRNA against either Cyclin T2 or Cyclin T1. As a control, cells were transduced with shRNA...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-28339 | biostudies-arrayexpress
TranscriptomicsThe permanent reduction of TIA proteins molds expression transcriptome in HeLa cells
This study provides, for the first time, TIA1 and TIAR linked-transcriptomic analysis by using RNA-Seq next-generation sequencing technology. Illumina RNA-Seq was used to survey transcriptome profiles from permanent TIA1- and TIAR-(shRNA-mediated) deficient HeLa cells. Analysis of the transcriptomes...
ORGANISM(S): Homo sapiens 
2014-11-19 | E-GEOD-46516 | biostudies-arrayexpress
ProteomicsEvaluation of different data-driven rescoring platforms to increase peptide identifications in HeLa digest samples
Evaluate the performance of different rescoring platforms with the aim of standardizing pipelines within our research group.
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052875 | Pride
Hela samples Rescoring pipelines 
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