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ProteomicsBlue native electrophoresis combined with stable isotope labeling shows that Saccharomyces cerevisiae mitochondrial respiratory chain supercomplexes are still present under anaerobic conditions
Not available
ORGANISM(S): Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) 
2009-07-28 | PRD000087 | Pride
ProteomicsThe E3 ubiquitin ligase HectD3 is a novel regulator of cardiac hypertrophy and inflammation
The HECT domain E3 ubiquitin protein ligase 3 (HectD3) is highly expressed in the heart, but its cardiac function is still unknown. Here, we identified SUMO2 and Stat1 as novel cardiac substrates for HectD3. SUMO2 is a potent inducer of Calcineurin-NFAT mediated cardiomyocyte hypertrophy, whereas, S...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-09 | PXD020843 | Pride
Ubiquitin ligase Cardiac models Proteomics 
ProteomicsSCX, 18O-labeling and charge reversal for C-terminomics
The proteome wide, mass spectrometry based identification of protein C-termini is hampered by factors such as poor ionization efficiencies, low yields in labeling strategies or the need for enrichment procedures. We present a bottom-up proteomics workflow to identify protein C-termini utilizing a co...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-06-20 | PXD013486 | Pride
Lc-ms Charge-reversal derivatization C-terminomics 
ProteomicsExopeptidase assisted N- and C-terminal proteome sequencing
Due to mechanisms such as alternative translation starts or proteolytic processing, in-vivo proteoforms do not necessarily correspond to those encoded in the genome. Therefore, knowledge of protein termini is an indispensable prerequisite to understand protein function. Sequencing of protein N- and ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-10-15 | PXD015612 | Pride
Protein sequencing Proteomics Terminomics 
UnknownThe IL-33-induced p38-/JNK1/2-TNFα axis is antagonized by activation of β-adrenergic-receptors in dendritic cells.
Not available
S-EPMC7235212 | biostudies-literature
ProteomicsMultidimensional separation schemes enhance the identification and molecular characterization of low molecular weight proteomes and short open reading frame encoded peptides in top-down proteomics
In the present work we developed a sample preparation approach for the combined bottom-up and top-down proteomics analysis of small open reading frame encoded proteins (SEP). Key improvements were made by the application of solid phase extraction (SPE) supported enrichment of LMW proteins, followed ...
ORGANISM(S): Methanosarcina mazei Go1 
2021-11-02 | PXD019792 | Pride
Microprotein Sep 
ProteomicsDegradome of soluble ADAM10 and ADAM17 metalloproteases
Disintegrin and metalloproteinases ADAM10 and ADAM17 can release the extracellular region of a variety of membrane-bound proteins including cytokines, adhesion molecules, growth factors and receptors, important for many biological functions (ectodomain shedding).. So far, substrate identification fo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-06-24 | PXD013718 | Pride
Lc-ms Tails Metalloproteases 
Proteomicstrypsin_AHSG_Hec293_r
Refined version of low-pH strong cation exchange, Trypsin r2
ORGANISM(S): Homo Sapiens (human) 
2009-12-31 | PAe005308 | PeptideAtlas
Proteomicstrypsin_AHSG_Hec293
Refined version of low-pH strong cation exchange, Trypsin r1
ORGANISM(S): Homo Sapiens (human) 
2009-12-31 | PAe005306 | PeptideAtlas
ProteomicsLysC_AHSG_Hec293
Refined version of low-pH strong cation exchange, LysC
ORGANISM(S): Homo Sapiens (human) 
2009-12-31 | PAe005307 | PeptideAtlas
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