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ProteomicsTowards understanding male infertility after spinal cord injury through quantitative proteomics
The study of male infertility after spinal cord injury (SCI) has enhanced the understanding of seminal plasma (SP) as an important regulator of spermatozoa function. However, the most important factors leading to the diminished sperm motility and viability observed in semen of men with SCI remained ...
ORGANISM(S): Homo sapiens (Human) 
2016-02-01 | PXD002145 | Pride
Anejaculation Human seminal plasma Spinal cord injury Male infertility Quantitative proteomics Lc-ms/ms 
ProteomicsComparison of In-Gel and SP3 Mass Spectrometry Sample Preparation Protocols
Sensitivity, robustness, and reproducibility of sample preparation are main determinants of data quality in bottom-up mass spectrometry-based proteomics. To this end, in-gel protein clean-up and digestion has been used for decades and is characterized by its robustness and compatibility with harsh l...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD064954 | Pride
ProteomicsActive repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis
Cell fate plasticity enables development, yet unlocked plasticity is a cancer hallmark. Regulating cell identity requires gene activation and repression. While master regulators induce lineage-specific genes to restrict plasticity, it remains unclear whether unwanted plasticity is actively suppresse...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-11 | PXD053043 | Pride
Cell fate plasticity Gene regulation Transcriptional repression Liver cancer Prox1 
ProteomicsThe gut microbiota promotes hepatic fatty acid desaturation and elongation in mice
Interactions between the gut microbial ecosystem and host lipid homeostasis are highly relevant to host physiology and metabolic diseases. We present a comprehensive multi-omics view of the effect of intestinal microbial colonization on hepatic lipid metabolism, integrating transcriptomic, proteomic...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-20 | PXD010412 | Pride
Fatty acyls Fatty acid signature Microbiome Lipidomics Lipid metabolism Stable isotope labelling Classification score Data integration Short chain fatty acids 
ProteomicsChemical phosphoproteomic approaches reveal substrate specificity of phosphoprotein phosphatases-1 and -2
The phosphatases PP1 and PP2A are responsible for the majority of dephosphorylation reactions on phosphoserine (pSer) and –threonine (pThr), and are involved in basically all cellular processes and many related diseases. They are thought to have no appreciable intrinsic substrate specificity, but ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-14 | PXD013775 | Pride
Phospho peptide library Pp2a Pp1 
ProteomicsTarget Landscape of Clinical Kinase Inhibitors
Here, we provide a comprehensive overview of the selectivity profiles of 242 kinase inhibitors currently in clinical trials. We screened available inhibitors against human protein kinases by using the Kinobead technology resulting in a drug matrix identifying the druggable kinome and related protein...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-12 | MSV000081932 | MassIVE
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