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ProteomicsPre-Analytical Framework for Routine Clinical Use of Liquid Biopsies: Combining EVs and cfDNA
Liquid biopsies hold significant potential for the non-invasive diagnostics of tumors and other diseases. While the clinical application of cell-free DNA (cfDNA) methodologies is emerging, the implementation of tumor-derived extracellular vesicles (EVs) as validated biomarkers is hindered by substan...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD062837 | Pride
Extracellular vesicles Liquid biopsy Cfdna Human plasma Tube preservation Isolation protocol Pre-analytics Translation 
ProteomicsA translational protocol for the analysis of plasma-derived extracellular vesicle proteomics
We establish here an EV purification and proteomic analysis workflow in a real world clinical setting in which we evaluate different variables, from blood collection through protein preparation for mass spectrometry (MS). We compare blood collection tubes, sample transportation and storage condition...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD058373 | Pride
Protocol Proteomics Preanalytics Liquid biopsy Plasma Extracellular vesicles Translation 
ProteomicsPlatelet-phenotypes in chronic inflammation
In addition to their well-established role in thrombosis and hemostasis, there is growing evidence that platelets play a central role in systemic inflammatory processes. Therefore, we aimed to gain insights into the phenotype and possible platelet-subgroups in the context of different types of infla...
ORGANISM(S): Homo sapiens (Human) 
2025-10-08 | PXD057615 | Pride
Type 2 inflammation Platelets Psoriasis Type 3 inflammation Atopic dermatitis 
ProteomicsTarget Landscape of Clinical Kinase Inhibitors
Here, we provide a comprehensive overview of the selectivity profiles of 242 kinase inhibitors currently in clinical trials. We screened available inhibitors against human protein kinases by using the Kinobead technology resulting in a drug matrix identifying the druggable kinome and related protein...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-12 | MSV000081932 | MassIVE
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