Hematopoietic cancer cells

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Unknown (6240)
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Genomic (4)
Multiomics (1)

Organisms

Homo sapiens (758)
Mus musculus (623)
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synthetic construct (2)
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unidentified plasmid (1)

Organisms

Mus musculus (561)
Homo sapiens (428)
Macaca mulatta (5)
Danio rerio (3)
Macaca nemestrina (2)
Drosophila melanogaster (2)
Mus (1)
Canis lupus familiaris (1)
Mus musculus musculus (1)

Repository

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biostudies-arrayexpress (833)
geo (382)
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pride (65)
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iProX (2)

Tissue

Blood cell (12)
Blood (11)
Cell culture (11)
Bone marrow (7)
Stem cell (6)
B cell (5)
Cell suspension culture (5)
Leukocyte (5)
Fibroblast (3)
Cerebrospinal fluid (2)
Hematopoietic cell (2)
Primary cell (2)
Soft tissue sarcoma cell (2)
T cell (2)
Acute lymphoblastic leukemia cell line (1)
Bone marrow hematopoietic cell (1)
Cerebrospinal fluid secretion (1)
Connective tissue type mast cell (1)
Early embryonic cell (1)
Embryonic fibroblast (1)
Embryonic stem cell (1)
Epithelial cell (1)
Epithelial cell of cervix (1)
Erythroblast (1)
Erythroid progenitor cell (1)
Haematopoietic stem cells (1)
Hematopoietic progenitor cell differentiation (1)
JURKAT cell (1)
Leukemia cell (1)
Macrophage (1)

Disease

Acute leukemia (13)
Chronic myeloid leukemia (5)
Normal (4)
Acute myeloid leukemia (4)
Lymphoma (3)
Not Available (3)
Disease free (3)
Burkitt Lymphoma (2)
Carcinoma (2)
Idiopathic myelofibrosis (1)
Ewing family tumor (1)
4T1 tumor-bearing (1)
Erythroleukemia (1)
AIDS-KS, HIV+, nodular (late) stage (1)
Polycythemia vera (1)
Locally advanced rectal cancer (1)
Chronic myelogenous leukemia (1)
Acute promyelocytic leukemia (1)
Neurofibromatosis type 1 (1)
Colorectal Neoplasms (1)
Neoplasms (1)
Acute T cell leukemia (1)
Bone marrow (1)
Brain cancer (1)
Breast cancer (1)
Burkitt lymphoma (1)
Cervix carcinoma (1)
Colon cancer (1)
Lymphoma (1)
Melanoma (1)

Technology Type

Mass Spectrometry (65)
Shotgun proteomics (41)
Affinity purification coupled with mass spectrometry proteomics (12)
Bottom-up proteomics (12)
Mass spectrometry (8)
Gel-based experiment (6)
Data-independent acquisition (5)
Illumina HiSeq 2000 (3)
Illumina HiSeq 2500, ILLUMINA (3)
Data-dependent acquisition (3)
Mass spectrometry assay (2)
Illumina CytoSNP, Illumina HumanOmni2.5, ILLUMINA, Illumina 450k, Illumina HiSeq 2000 (1)
Illumina HiSeq 2000, HumanMethylation450k Bead Chip - Genome Studio, Illumina Genome Analyzer IIx (1)
Illumina HiSeq 2000, ILLUMINA, Illumina HiSeq 2500 (1)
Illumina HiSeq 2500, Illumina MiSeq, NextSeq 500, Illumina HiSeq 2000 (1)
Ion Torrent Proton, Illumina MiSeq, NextSeq 550 (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)
DiaPASEF (1)
HDMSE (1)
SWATH MS (1)

Instrument Platform

Illumina NovaSeq 6000 (58)
NextSeq 500 (18)
Illumina HiSeq 2500 (17)
Illumina HiSeq 2000 (14)
Illumina HiSeq 4000 (11)
NextSeq 550 (7)
Illumina HiSeq 3000 (6)
NA (3)
HiSeq X Ten (3)
10x Genomics Chromium (2)
Flow Cytometer (2)
Illumina NovaSeq X (2)
10x Genomics Chromium Controller (2)
NextSeq 2000 (2)
Illumina HiSeq 1500 (2)
FACSAria III (BD Sciences) (1)
Chromium Controller with Chromium Next GEM Single Cell 5’ and V(D)J (kits v1.1) (1)
NextSeq 500, 75 bp single end lane (1)
BD Rhapsody Express Instrument (1)
Real-time PCR Thermal Cycler (1)
Thermomixer (1)
BD FACS ARIA III analyser (1)
HPC (1)
Sequel II (1)
G2565BA Microarray Scanner (1)
SMARTerTM Ultra Low RNA Kit (1)
Not applicable (1)
GeneChip Scanner 3000 7G (1)
G2565BA DNA microarray scanner [Agilent] (1)
ScanArray Express HT (1)

Publication Date

2015 (146)
2013 (111)
2012 (101)
2014 (99)
2025 (86)
2010 (86)
2023 (85)
2021 (72)
2011 (69)
2016 (67)
2019 (56)
2022 (49)
2026 (48)
2020 (45)
2008 (43)
2024 (42)
2018 (37)
2009 (32)
2017 (23)
2007 (10)
2006 (7)
2005 (4)
2004 (2)

CHEBI ID

CHEBI:15354 (4)
CHEBI:16347 (4)
CHEBI:17750 (4)
CHEBI:32816 (4)
CHEBI:116314 (3)
CHEBI:16450 (3)
CHEBI:16708 (3)
CHEBI:16750 (3)
CHEBI:17154 (3)
CHEBI:17368 (3)
CHEBI:17376 (3)
CHEBI:17533 (3)
CHEBI:17562 (3)
CHEBI:18186 (3)
CHEBI:18237 (3)
CHEBI:22653 (3)
CHEBI:22660 (3)
CHEBI:25351 (3)
CHEBI:27891 (3)
CHEBI:30769 (3)
CHEBI:30915 (3)
CHEBI:6650 (3)
CHEBI:100241 (2)
CHEBI:10072 (2)
CHEBI:15318 (2)
CHEBI:15356 (2)
CHEBI:15373 (2)
CHEBI:15428 (2)
CHEBI:15603 (2)
CHEBI:15676 (2)

Metabolite Name

Hypoxanthine (4)
3'-AMP (3)
AMP (3)
Adenine (3)
Betaine (3)
Choline (3)
Creatinine (3)
Cytidine (3)
Difloxacin (3)
Folic acid (3)
Ornithine (3)
1-Methylnicotinamide (2)
2-Isopropylmalic acid (2)
4-Hydroxyquinoline (2)
4-Nitrophenol (2)
5-Hydroxytryptophan (2)
5-Methylcytosine (2)
Acetanilide (2)
Adenosine (2)
Amphetamine (2)
Arginine (2)
Beclomethasone (2)
Benzoic acid (2)
Carbazole (2)
Chlormadinone acetate (2)
Cholesterol (2)
Citramalic acid (2)
Citric acid (2)
Creatine (2)
Cyanazine (2)

First Public Date

2014 (158)
2025 (134)
2024 (119)
2023 (113)
2026 (89)
2022 (89)
2021 (85)
2019 (76)
2018 (67)
2020 (65)
2015 (53)
2016 (35)
2013 (20)
2017 (17)

Modelling Approach

Ordinary differential equation model (4)

Study status

Completed (3)
Active, not recruiting (2)
Recruiting (2)
Withdrawn (2)

Lab affiliation

Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (2)
Department of Cellular Immunology, German Cancer Research Center Heidelberg, Germany (2)
Institute of Clinical Sciences, Department of Oncology, Lund University, Sweden (2)
Leiden University Medical Centre (LUMC) (2)
., Department of Laboratory Medicine, Medical University of Vienna, 18-20 Währinger Gürtel, 1090 Vienna, Austria (1)
1 Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France. Equipe labellisée par la Ligue contre le cancer 2 Infrastructure Nationale de Protéomique, ProFI, FR 2048, Toulouse, France. (1)
1 Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada 2 Department of Molecular Genetics, University of Toronto, Toronto, ON M5S1A5, Canada (1)
1)Program for Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (PMPPC-IGTP), 08916 Badalona, Spain 2)Cancer and Leukemia Epigenetics and Biology Program, Josep Carreras Leukaemia Research Institute (IJC), Campus ICO-GTP-UAB, 08916 Badalona, Spain (1)
1. INSERM U1287, Université Paris-Saclay, Gustave Roussy Cancer Center, Villejuif, France 2. Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre, France (1)
1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA 2Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA 3Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA (1)
1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. 2Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. 3Biological and Biomedical Sciences Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. (1)
Cancer Research Institute, Beth Israel Deaconess Cancer Center Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. (1)
Cell Signaling and Proteomics Group, Center for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK. (1)
Center for Cell Engineering, Memorial Sloan Kettering Cancer Center (1)
Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London (1)
Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet SE 17177 Stockholm, Sweden. Department of Pharmacological & Technological Chemistry, I.M. Sechenov First Moscow State Medical University, Moscow, 119146, Russia. (1)
Committee on Cancer Biology, The University of Chicago, Chicago, IL, USA Department of Pathology, The University of Chicago, Chicago, IL, USA Department of Pediatrics, The University of Chicago, Chicago, IL, USA The University of Chicago Medicine Comprehensive Cancer Center, University of Chicago, Chicago, IL, USA (1)
DNA damage responses and cancer lab Department of Human Genetics Leiden University Medical Center Eithovenweg 20 2333ZC Leiden The Netherlands (1)
Department of Biochemistry, Biophysics and General Pathology, University of Campania “Luigi Vanvitelli”, Vico L. De Crecchio 7, 80138 Napoli, IT (1)
Department of Cancer Biology, University of Cincinnati, Cincinnati, Ohio 45267, USA (1)
Department of Chemistry & Chemical Biology, Northeastern University (1)
Department of Genetics, Cell Bioliogy, & Anatomy Buckley Lab University of Nebraska Medical Center Omaha, Nebraska United States of America (1)
Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China (1)
Department of Internal Medicine V, Heidelberg University Hospital, 69120 Heidelberg, Germany (1)
Department of Laboratory Medicine and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, United States of America (1)
Department of Medicine and Life Sciences, Pompeu Fabra University, 08003, Barcelona, Spain. (1)
Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N-0379 Oslo, Norway (1)
Department of Oncology, KU Leuven (1)
Department of Oncology, Laboratory for Disease mechanisms in cancer, KU Leuven Campus Gasthuisberg O&N1, Herestraat 49 - box 603 3000 Leuven (Belgium) (1)
Department of Pathology, School of Medicine, Saint Louis University, United States, St. Louis VA Medical Center(VHA), United States (1)

Keyword

Fludarabine (2)
Fludarabine phosphate (2)
Mycophenolic Acid (2)
Nivolumab (2)
Adult nasal type extranodal NK/T-cell lymphoma (1)
Anaplastic large cell lymphoma (1)
Anti-Bacterial Agents (1)
Contiguous stage II adult diffuse large cell lymphoma (1)
Contiguous stage II grade 1 follicular lymphoma (1)
Contiguous stage II grade 2 follicular lymphoma (1)
Contiguous stage II grade 3 follicular lymphoma (1)
Contiguous stage II mantle cell lymphoma (1)
Cyclophosphamide (1)
Cyclosporine (1)
Cyclosporins (1)
Dabrafenib (1)
Dimethyl Sulfoxide (1)
Heptavalent Pneumococcal Conjugate Vaccine (1)
Ipilimumab (1)
Noncontiguous stage II adult diffuse large cell lymphoma (1)
Noncontiguous stage II grade 1 follicular lymphoma (1)
Noncontiguous stage II grade 2 follicular lymphoma (1)
Noncontiguous stage II grade 3 follicular lymphoma (1)
Noncontiguous stage II mantle cell lymphoma (1)
Recurrent adult Hodgkin lymphoma (1)
Recurrent adult diffuse large cell lymphoma (1)
Recurrent grade 1 follicular lymphoma (1)
Recurrent grade 2 follicular lymphoma (1)
Recurrent grade 3 follicular lymphoma (1)
Recurrent mantle cell lymphoma (1)

IsPrivate

False (4)

Modification

144.102062 (1)
15.994915 (1)
45.987721 (1)

Study type

Transcription profiling by array (498)
RNA-seq of coding RNA (112)
ChIP-seq (53)
RNA-seq of coding RNA from single cells (42)
Methylation profiling by array (26)
Methylation profiling by high throughput sequencing (15)
Comparative genomic hybridization by array (14)
Other (11)
ATAC-seq (6)
Unknown experiment type (5)
ChIP-chip by tiling array (5)
DNA-seq (5)
Animal - High-throughput sequencing (4)
RNA-seq of non coding RNA (4)
Transcription profiling by RT-PCR (3)
Transcription profiling by SAGE (2)
Differential (2)
Human - Single-cell sequencing (2)
Human - High-throughput sequencing (2)
Cell line - High-throughput sequencing (2)
RNAi profiling by array (2)
Genotyping by array (2)
Spatial transcriptomics by high-throughput sequencing (2)
CUT&RUN (2)
RNA-seq of total RNA (2)
Baseline (1)
Animal - One-color microarray (1)
MicroRNA profiling by high-throughput sequencing (1)
Animal - Single-cell sequencing (1)
High-throughput sequencing (1)

Release Date

2021 (657)
2022 (606)
2023 (573)
2020 (516)
2025 (448)
2015 (438)
2019 (435)
2016 (410)
2018 (407)
2024 (404)
2014 (381)
2017 (364)
2013 (290)
2012 (272)
2011 (191)
2010 (175)
2009 (125)
2008 (110)
2026 (71)
2007 (67)
2006 (48)
2005 (31)
2004 (15)
2001 (8)
2003 (7)
1998 (7)
2002 (6)
1999 (4)
1997 (4)
2000 (2)

Location

United States (9)
Canada (3)
Italy (1)

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A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights

Hematopoietic stem cell derived conditioned media metabolomics

Metabolomic data of conditioned media derived from culturing hematopoietic stem cells.

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2025-02-14 | MSV000097113 | MassIVE

Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis (Affymetrix)

DNA methylation is tightly regulated throughout mammalian development and altered methylation patterns are a hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in acute myeloid leukemia (AML) and has been suggested to protect CpG islands and promoters from aberrant methyla...

ORGANISM(S): Mus musculus

2015-04-22 | E-GEOD-59586 | biostudies-arrayexpress

Transcription profiling of mouse adult bone marrow cells reveals candidate genes form expansion and transformation of hematopoietic stem cells by NUP98-HOX Fusion Genes

BACKGROUND: Hox genes are implicated in hematopoietic stem cell (HSC) regulation as well as in leukemia development through translocation with the nucleoporin gene NUP98. Interestingly, an engineered NUP98-HOXA10 (NA10) fusion can induce a several hundred-fold expansion of HSCs in vitro and NA10 and...

ORGANISM(S): Mus musculus

2008-06-17 | E-GEOD-9079 | biostudies-arrayexpress

Transcription profiling by array of human bone marrow hematopoietic stem cells from healthy young and elderly individuals

In the human hematopoietic system, aging is associated with decreased bone marrow cellularity, decreased adaptive immune system function, and increased incidence of anemia and other hematological disorders and malignancies. Recent studies in mice suggest that changes within the hematopoietic stem ce...

ORGANISM(S): Homo sapiens

2011-11-11 | E-GEOD-32719 | biostudies-arrayexpress

The Hematopoietic System - Myeloid arm

We used microarray to create a normal cell landscape for the myeloid arm of the hematopoietic system. Mononuclear bone marrow cells from heathly donors were enriched for 34+ and hematopoietic stem and progenitor cells were sorted by FACS.

ORGANISM(S): Homo sapiens

2014-01-01 | E-GEOD-42519 | biostudies-arrayexpress

MLL regulated genes in LSK/CD48- hematopoietic stem cells

The histone methyltransferase mixed lineage leukemia (MLL) is essential to maintain hematopoietic stem cells and is a leukemia protooncogene. Although Hox genes are well-characterized targets of MLL and MLL fusion oncoproteins, the range of Mll-regulated genes in normal hematopoietic cells remains u...

ORGANISM(S): Mus musculus

2013-05-24 | E-GEOD-47205 | biostudies-arrayexpress

Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis (eRRBS)

ORGANISM(S): Mus musculus

2015-04-22 | E-GEOD-59584 | biostudies-arrayexpress

H3K9me3 Cut&Tag on hematopoietic stem cells sorted from mice 1 month after they were irradiated (2Gy total body irradiation = IR) or not (non irradiated = NIR) and with or without prior TNFa treatment (IR_TNF)

Analysis of the RNA-seq data performed in IR vs NIR hematopoietic stem cells show the loss of the TNF_via_NFKB signature. We showed that the loss of this signature could be associated with H3K9me3 loss at specific retrotransposable elements . To validate this association, we tested if TNFa treatment...

ORGANISM(S): Mus musculus

2022-06-24 | E-MTAB-11864 | biostudies-arrayexpress

Hematopoietic stem cell conditioned media induces apoptosis in colorectal cancer stem cells via dysregulation of HSP90 and 26S proteasome system

Mallick et al. showed that the hematopoietic stem cells exhibited exclusive tropism towards colorectal cancer stem cells (CRC-CSC). HSCs-derived conditioned media disrupted the 26s proteasome, HSP90, inducing mitochondrial alteration and apoptosis in CRC CSCs.

ORGANISM(S): Homo sapiens (Human)

2025-05-08 | PXD057783 | Pride

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