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TranscriptomicsHeparan Sulfation Dependent FGF Signalling Maintains ES Cells Primed for Differentiation in a Heterogeneous State
Embryonic stem (ES) cells continuously decide whether to maintain pluripotency or differentiate. While exogenous LIF and BMP4 perpetuate a pluripotent state, less is known about factors initiating differentiation. We show that heparan sulfate (HS) proteoglycans are critical co-receptors for signals ...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-15974 | biostudies-arrayexpress
ProteomicsGalectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatase Sulf-2
Human extracellular 6-O-endosulfatases Sulf-1 and Sulf-2 are the only enzymes that post-synthetically alter the 6-O sulfation of heparan sulfate proteoglycans (HSPG), which regulates interactions of HSPG with many proteins. Oncogenicity of Sulf-2 in different cancers has been documented and we have ...
ORGANISM(S): Homo Sapiens (human) 
2024-04-25 | PXD051711 | JPOST Repository
ProteomicsGalectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatse Sulf-2
Human extracellular 6-O-endosulfatases Sulf-1 and Sulf-2 are the only enzymes that post-synthetically alter the 6-O sulfation of heparan sulfate proteoglycans (HSPG), which regulates interactions of HSPG with many proteins. Oncogenicity of Sulf-2 in different cancers has been documented and we have ...
ORGANISM(S): Homo Sapiens (human) 
2024-01-20 | PXD048713 | JPOST Repository
UnknownHeparan Sulfate Proteoglycans in Tauopathy.
Not available
S-EPMC9776397 | biostudies-literature
ProteomicsNovel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils
Synucleinopathies are characterized by the accumulation and propagation of α-synuclein (α-syn) aggregates throughout the brain, leading to neuronal dysfunction and death. In this study, we used an unbiased FACS-based genome-wide CRISPR/Cas9 knockout screening to identify genes that regulate the entr...
ORGANISM(S): Homo sapiens (Human) 
2025-09-25 | PXD065224 | Pride
Protein aggregates Genome-wide screen Crispr/cas9 Preformed fibrils Heparan sulfate proteoglycans Parkinson’s disease Alpha synuclein 
UnknownHeparan sulfate proteoglycans present PCSK9 to the LDL receptor.
Not available
S-EPMC5593881 | biostudies-literature
ProteomicsN- and O-Glycoproteomic Analysis of Complex Proteoglycans
Proteoglycans are a small but diverse family of proteins that play a wide variety of roles at the cell surface and extracellular matrix. In addition to their glycosaminoglycan (GAG) chains, they are also N- and O-glycosylated. All of these types of glycosylation are crucial to their function, but pr...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2025-05-06 | PXD041935 | Pride
Proteoglycans Glycoproteomics Tandem mass spectrometry 
UnknownFunctional overlap between chondroitin and heparan sulfate proteoglycans during VEGF-induced sprouting angiogenesis.
Not available
S-EPMC3331918 | biostudies-literature
UnknownInfection and transmission of SARS-CoV-2 depend on heparan sulfate proteoglycans.
Not available
S-EPMC8521309 | biostudies-literature
ProteomicsProteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin binding protein
Animal cells express heparan sulfate proteoglycans that perform many important cellular functions by way of heparan sulfate-protein interactions. The identification of membrane heparan-sulfate binding proteins is challenging because of their low abundance and the need for extensive enrichment. Here,...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2020-01-09 | MSV000084782 | MassIVE
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