Hepatosteatosis

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Unknown (337)
Genomics (63)
Transcriptomics (62)
Metabolomics (21)
Proteomics (12)

Organisms

Mus musculus (74)
Homo sapiens (4)

Organisms

Mus musculus (46)
Homo sapiens (6)

Repository

ENA (58)
geo (48)
MetaboLights (21)
biostudies-arrayexpress (19)
pride (9)
iProX (2)
MassIVE (1)

Tissue

Liver (7)
Cell culture (1)
Endothelial cell of hepatic sinusoid (1)
Kupffer cell (1)

Disease

Fatty liver disease (1)

Technology Type

Mass spectrometry assay (19)
Mass Spectrometry (9)
Shotgun proteomics (5)
Bottom-up proteomics (2)
Data-dependent acquisition (2)
Top-down proteomics (2)
Mass spectrometry (1)
NMR spectroscopy (1)

Instrument Platform

Liquid Chromatography MS - negative - reverse-phase (8)
Liquid Chromatography MS - positive - reverse-phase (7)
Liquid Chromatography MS - negative - hilic (5)
Liquid Chromatography MS - positive - hilic (5)
Liquid Chromatography MS - alternating - hilic (4)
Liquid Chromatography MS - positive - reverse phase (2)
Illumina NovaSeq X (1)
Illumina (1)
Illumina HiSeq 2500 (1)
Illumina HiSeq 4000 (1)
Orbitrap Fusion Lumos (1)
Q Exactive HF (1)
LECO Pegasus III (1)
Liquid Chromatography MS - alternating - reverse-phase (1)
Liquid Chromatography MS - negative - reverse phase (1)
Nuclear Magnetic Resonance (NMR) (1)

Publication Date

2026 (26)
2024 (11)
2022 (9)
2023 (7)
2025 (5)
2018 (5)
2014 (5)
2019 (5)
2015 (4)
2013 (4)
2011 (4)
2010 (3)
2021 (3)
2012 (2)
2020 (2)
2016 (1)
2017 (1)
2009 (1)
2027 (1)

CHEBI ID

CHEBI:15354 (2)
CHEBI:15428 (2)
CHEBI:15676 (2)
CHEBI:15741 (2)
CHEBI:15891 (2)
CHEBI:16027 (2)
CHEBI:16113 (2)
CHEBI:16199 (2)
CHEBI:16449 (2)
CHEBI:16704 (2)
CHEBI:16737 (2)
CHEBI:16811 (2)
CHEBI:17154 (2)
CHEBI:17596 (2)
CHEBI:18012 (2)
CHEBI:18186 (2)
CHEBI:18257 (2)
CHEBI:20067 (2)
CHEBI:24898 (2)
CHEBI:25017 (2)
CHEBI:26986 (2)
CHEBI:27266 (2)
CHEBI:28044 (2)
CHEBI:30915 (2)
CHEBI:36005 (2)
CHEBI:78320 (2)
CHEBI:1148 (1)
CHEBI:131887 (1)
CHEBI:132327 (1)
CHEBI:134598 (1)

Metabolite Name

Inosine (9)
4-Hydroxyproline (8)
Alanine (8)
Citric acid (8)
Dimethylglycine (8)
Fumaric acid (8)
Glyceric acid (8)
Ketoleucine (8)
Lactate (8)
Malic acid (8)
Methionine (8)
Oxypurinol (8)
Phe-Val (8)
Phosphate (8)
Sebacic acid (8)
Taurine (8)
Uridine (8)
Valeric acid (8)
(2S)-3-methyl-2-[[(2R)-5-oxopyrrolidine-2-carbonyl]amino]butanoic acid (7)
13-Ethenyl-5,7,9,11,13-pentamethyl-2-oxa-18-azahexacyclo[20.2.2.13,10.04,9.016,20.014,27]heptacosa-1(24),11,22,25-tetraene-15,17,19-trione (7)
2-Aminoadipic acid (7)
2-Hydroxy-2-methylbutyric acid (7)
2-Hydroxy-3-methylbutyric acid (7)
3-Hydroxybutyric acid (7)
4-Aminobutyric acid (GABA) (7)
4-Hydroxybenzaldehyde (7)
5-Aminolevulinic acid (7)
5-Aminopentanoic acid (7)
Adenosine (7)
Ala-Gly (7)

First Public Date

2024 (11)
2022 (9)
2023 (7)
2026 (6)
2020 (4)
2019 (4)
2014 (4)
2021 (3)
2018 (3)
2025 (2)
2017 (2)
2015 (2)
2013 (1)

Study type

Transcription profiling by array (14)
RNA-seq of coding RNA (3)
Spatial transcriptomics by high-throughput sequencing (1)
ChIP-seq (1)

Release Date

2022 (32)
2023 (30)
2020 (30)
2017 (30)
2021 (29)
2018 (27)
2019 (25)
2015 (22)
2014 (19)
2025 (18)
2024 (17)
2013 (16)
2016 (14)
2012 (14)
2011 (13)
2010 (8)
2026 (6)
2008 (4)
2009 (1)
2007 (1)

Lab affiliation

The University of Sydney (2)
Department of Molecular Integrative Physiology University of Illinois at Urbana/Champaign Urbana, IL 61801 (1)
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA (1)
Institute of BioMedical and Oral Research, Faculty of Dental Medicine, Hebrew University- Ein Kerem Campus, P. O. Box 12272, Jerusalem 9112102, Israel (1)
Karolinska Institute Division of Molecular Metabolism Department of Medical Biochemistry and Biophysics (1)
Max-Planck Instutute of Biochemistry, Martinsrfied, Germany (1)
Sul Lab, NST, UC Berkeley (1)
The Hong Kong Polytechnic University (1)

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Inhibition of mammalian mtDNA transcription in liver reprograms metabolism to reverse diet-induced obesity and hepatosteatosis

The oxidative phosphorylation (OXPHOS) system in mammalian mitochondria plays a key role in harvesting energy from different types of ingested nutrients1,2. Mitochondrial metabolism is very dynamic and can be reprogrammed to support both catabolic and anabolic reactions, depending on physiological d...

ORGANISM(S): Mus musculus (Mouse)

2024-03-28 | PXD034771 | Pride