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ProteomicsPathogenic POLRMT variants in mice impair mtDNA transcription and affect perinatal survival
Mitochondrial gene expression is essential for oxidative phosphorylation (OXPHOS) that generates the bulk of the cellular ATP, and dysfunctional mitochondria is a common cause of human metabolic diseases. Recently, the first pathogenic variants in the only known mitochondrial RNA polymerase (POLRMT)...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-13 | PXD074595 | Pride
Mouse models Mtdna Mitochondria Polrmt 
TranscriptomicsRNAi profiling of human transcripts affected by RNAi to POLRMT
Rho0 HeLa cells (devoid of mitochondrial DNA and functional mitochondria) were infected with recombinant lentiviral vector pLSLG expressing short hairpin RNAi complementary to Exons 3 and 17 of POLRMT gene. 48 hours after infection total RNA was isolated and analyzed for inhibition of POLRMT transc...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2478 | biostudies-arrayexpress
TranscriptomicsPOLRMT regulates the switch between replication-primer formation and gene expression of mammalian mtDNA
Mitochondria are vital in providing cellular energy via their oxidative phosphorylation system, which requires the coordinated expression of genes encoded by both the nuclear and mitochondrial genomes (mtDNA). Transcription of the circular mammalian mtDNA depends on a single mitochondrial RNA polyme...
ORGANISM(S): Mus musculus 
2016-08-05 | E-GEOD-83368 | biostudies-arrayexpress
TranscriptomicsExpression data for knockdown of POLRMT or RNA PolII in MCF-7 cell line
Transcription of mRNA in mammalian is mainly performed by RNA polymerase II (PolII). POLRMT is responsible for the production of cytoplasmic and nuclear form of mitochondrial RNA polymerase. The former (mtRNAP) participates in transcription of RNA in the mitochondria while the latter (spRNAP-IV) is ...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-28503 | biostudies-arrayexpress
GenomicsChIP analysis trial of human TFB2M and POLRMT interaction with mtDNA
ChIP analysis trial of human TFB2M and POLRMT interaction with mtDNA
PRJNA678680 | ENA
ProteomicsMitochondrial RNA polymerase overexpression enhances transcription initiation and exercise capacity without increasing mature mtRNA levels
POLRMT is the sole RNA polymerase in human mitochondria, where it generates primers for mitochondrial DNA (mtDNA) replication and transcribes the mtDNA to express genes encoding essential components of the oxidative phosphorylation (OXPHOS) system. Elevated POLRMT levels are found in several cancers...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-10 | PXD068527 | Pride
Polrmt Mitochondria Label-free Dda 
TranscriptomicsTranscripts affected by RNAi to POLRMT
Rho0 HeLa cells (devoid of mitochondrial DNA and functional mitochondria) were infected with recombinant lentiviral vector pLSLG expressing short hairpin RNAi complementary to Exons 3 and 17 of POLRMT gene. 48 hours after infection total RNA was isolated and analyzed for inhibition of POLRMT transcr...
ORGANISM(S): Homo sapiens 
2005-04-05 | GSE2478 | GEO
UnknownTargeting POLRMT by IMT1 inhibits colorectal cancer cell growth.
Not available
S-EPMC11372113 | biostudies-literature
TranscriptomicsPOLRMT regulates the switch between replication-primer formation and gene expression of mammalian mtDNA
Mitochondria are vital in providing cellular energy via their oxidative phosphorylation system, which requires the coordinated expression of genes encoded by both the nuclear and mitochondrial genomes (mtDNA). Transcription of the circular mammalian mtDNA depends on a single mitochondrial RNA polyme...
ORGANISM(S): Mus musculus 
2016-08-05 | GSE83368 | GEO
UnknownPOLRMT mutations impair mitochondrial transcription causing neurological disease.
Not available
S-EPMC7893070 | biostudies-literature
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