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ProteomicsMetabolism of ethylene and epoxyethane by the methanotrophic bacterium Methylohalobius crimeensis
M. crimeensis contains an operon with a putative pathway for catabolic oxidation of epoxyethane to acetyl CoA. Proteomics was used to meausure the expression of the proteins encoded by this operon before and after ethylene exposure.
ORGANISM(S): Methylohalobius crimeensis 10Ki 
2024-12-09 | PXD051614 | Pride
Methylohalobius crimeensis Ethylene Epoxyethane 
ProteomicsIntegrative Threading of the DNA-PKcs Disordered Region with Crosslinking Restraints
Integrative structure modelling was applied to understand how auto-phosphorylation of the ABCDE cluster in DNA-PKcs can occur. We used crosslinking restraints to assign sequence to structurally unassigned helices in DNA-PKcs s in the largely disordered region containing the ABCDE cluster. Our final ...
ORGANISM(S): Homo sapiens (Human) 
2019-12-10 | PXD016639 | Pride
Crosslinking-ms Integrative modelling Dna-pkcs 
ProteomicsKinetic Analysis of DNA Dependent Protein Kinase Catalytic Subunit
We investigated the dynamics of protein kinase DNA dependent protein kinase catalytic subunit (DNA-PKcs) through hydrogen deuterium exchange mass spectrometry. Over 1100 peptides could be monitored throughout the kinetics experiment, showing the utility of our nanospray HX-MS configuration for ultr...
ORGANISM(S): Homo sapiens (Human) 
2019-12-10 | PXD016595 | Pride
Hdx-ms Nanospray hx-ms Human Dna-pkcs 
ProteomicsIntegrative Structural Model of DNA-PK Synapsis
In non-homologous end joining repair of DNA double strand breaks, DNA dependent protein kinase catalytic subunit (DNA-PKcs) and Ku70/80 binds the free DNA ends forming the holoenzyme DNA-PK. DNA-PK synapses across the break to tether the broken ends in the initial long range synaptic complex. We gen...
ORGANISM(S): Homo sapiens (Human) 
2021-01-20 | PXD017931 | Pride
Dna-pk Hydrogen deuterium exchange Crosslinking 
ProteomicsRecommendations for Automating Hydrogen/Deuterium Exchange Mass Spectrometry Measurements using Data-Independent Acquisition Methods
Two test HX-DIA datasets, Phosphorylase B kinetics and nanobody binding, that can be used to explore the features of DIA-HX and the AutoHX software.
ORGANISM(S): Homo sapiens (Human) 
2025-01-22 | PXD060028 | Pride
Autohx Data-independent acquistion Hx-ms2 Hydrogen deuterium exchange Hx-dia 
UnknownThe Georgia Memory Net: Implementation of a statewide program to diagnose and treat Alzheimer's disease and related dementias.
Not available
S-EPMC9306650 | biostudies-literature
UnknownEfficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico.
Not available
S-EPMC8693692 | biostudies-literature
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