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ProteomicsIDENTIFICATION OF THE CANIDAE IRON REGULATORY HORMONE HEPCIDIN
Quantification and characterisation of canine hepcidin by LC-MS
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2020-05-26 | PXD015661 | Pride
Lc-ms Hepcidin Canine 
TranscriptomicsGut hepcidin: a key regulator of inflammation
Hepcidin is demonstrated to be the key iron regulatory hormone, produced by the liver. Here we show an unexpected role of hepcidin as a master initiator of the local and systemic inflammatory response. We found that hepcidin was highly expressed in the colon of two major idiopathic inflammatory bowe...
ORGANISM(S): Mus musculus 
2016-07-16 | E-GEOD-71073 | biostudies-arrayexpress
TranscriptomicsThe Small Molecule Genistein Increases Hepcidin Expression in Human Hepatocytes
Hepcidin, a peptide hormone that decreases intestinal iron absorption and macrophage iron release, is a potential drug target for patients with iron overload syndromes because its levels are inappropriately low in these individuals. Endogenous stimulants of Hepcidin transcription include bone morph...
ORGANISM(S): Homo sapiens 
2015-08-13 | E-GEOD-40069 | biostudies-arrayexpress
TranscriptomicsA strong anti-inflammatory signature revealed by liver transcription profiling of Tmprss6-/- mice
Tmprss6 is the master inhibitor of hepcidin and its inactivation causes iron refractory iron deficiency anemia both in human and in mice. Mice with iron deficiency anemia (IDA)-low hepcidin show a pro-inflammatory response that is blunted in iron deficienct-high hepcidin Tmprss6 null mice. We invest...
ORGANISM(S): Mus musculus 
2013-10-09 | E-GEOD-46287 | biostudies-arrayexpress
GenomicsEffect of the overexpression of hepcidin in the skin
Effect of the overexpression of hepcidin in the skin
PRJNA912222 | ENA
GenomicsOsteocytes produce erythroferrone to regulate liver hepcidin during stress erythropoiesis
Osteocytes produce erythroferrone to regulate liver hepcidin during stress erythropoiesis
PRJNA1008726 | ENA
TranscriptomicsA Liver Hepcidin-Intestinal HIF-2α Axis Regulates Iron Absorption During Systemic Iron Deficiency, Hypoxia and Hemochromatosis
Iron-related disorders are among the most prevalent diseases worldwide. Systemic iron homeostasis requires hepcidin (Hamp), a hepatic-derived hormone that controls iron mobilization through its molecular target, ferroportin (FPN), the only known mammalian iron exporter. Here, we took a transcriptomi...
ORGANISM(S): Mus musculus 
2018-12-12 | E-MTAB-7329 | biostudies-arrayexpress
TranscriptomicsGut hepcidin: a key regulator of inflammation
Hepcidin is demonstrated to be the key iron regulatory hormone, produced by the liver. Here we show an unexpected role of hepcidin as a master initiator of the local and systemic inflammatory response. We found that hepcidin was highly expressed in the colon of two major idiopathic inflammatory bowe...
ORGANISM(S): Mus musculus 
2019-02-14 | GSE71073 | GEO
TranscriptomicsHepcidin: a key regulator of inflammation
Hepcidin is demonstrated to be the key iron regulatory hormone, produced by the liver. Here we show an unexpected role of hepcidin as a master initiator of the local and systemic inflammatory response. We demonstrated that Hepcidin is a key new essential component of the immune system and may be a p...
ORGANISM(S): Mus musculus 
2021-02-13 | GSE95162 | GEO
GenomicsDendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing
Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing
PRJNA579388 | ENA
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