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ProteomicsHuman Hepatocyte Proteome
Here we report a comprehensive proteomic analysis of purified human hepatocytes and a human hepatoma cell line HepG2. The complete dataset comprises 9,400 proteins and provides quantitative depiction of the proteomes of hepatocytes and HepG2 cells at the protein titer and copy number dimensions.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-07 | MSV000079562 | MassIVE
ProteomicsCopper binding proteins identified by LC-MSMS from HepG2 cell
Copper is an essential micronutrient trace metal element for all living cells. To study the function of copper in cell cycle, we isolated copper binding proteins by using IMAC resin charged with copper, then identified the binding proteins by LC-MSMS. Cell cycle related proteins which binding copper...
ORGANISM(S): Homo sapiens (Human) 
2025-02-22 | PXD054518 | Pride
Hepg2 cell lc-msms 
ProteomicsiTRAQ-Based Quantitative Proteomic Analysis of Inhibitory Effects of Polysaccharides from Viscum coloratum (Kom.) Nakai on HepG2 Cells
Viscum coloratum (Kom.) Nakai is a variety of biological activities of medicinal plants, and the active component such as polysaccharides or alkaloids, also proved to have the effect of anti-tumor, anti-virus, anti-radiation, anti-oxidation and anti-infection. In this study, we examined the inhibiti...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005323 | Pride
Proteomic Itraq Hepg2 Viscum coloratum 
ProteomicsIdentification of interaction partners of novel polyacetylene
To elucidate molecular interaction partners of a novel plant-derived polyacetylene, we used a biotin-labelled polyacetylene in two cell lines (HEK293 and HepG2) and performed biotin-pulldown assays and proteomic analyses via LC-MSMS.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD037671 | Pride
Lc-msms Biotin-label compound Human cell lines 
ProteomicsTMT-proteomics of AUF1 knockdown in HepG2 cell
HepG2 cells is knockdown with siAUF1 or siNC, total cellular proteins were extracted with SDT buffer and quantified. The protein samples underwent FASH enzymatic digestion and TMT labeling, followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis.
ORGANISM(S): Homo Sapiens 
2024-01-24 | PXD048822 |
UnknowniTRAQ-Based Quantitative Proteomic Analysis of the Inhibitory Effects of Polysaccharides from Viscum coloratum (Kom.) Nakai on HepG2 Cells.
Not available
S-EPMC5496916 | biostudies-literature
ProteomicsTranscriptomic and Proteomic Response of HC-04 to hepatocyte growth factor (HGF)
The routine study of human malaria liver-stage biology in vitro is hampered by low infection efficiency of human hepatocellular carcinoma (HCC) lines (<0.1%), poor understanding of steady-state HCC biology, and lack of appropriate tools for trace sample analysis. HC-04 is the only HCC that supports ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079959 | MassIVE
ProteomicsLabel-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line
Hepatitis B virus (HBV) infection is a major health problem worldwide. Recent evidence suggests that various viruses can manipulate the infection process by secretion of specific viral and cellular components into exosomes, small nanometer-sized (30-150 nm) vesicles secreted from various cells. Howe...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080718 | MassIVE
TranscriptomicsComparative proteomic and RNA-seq analyses identify glypican-3 as a hepatocyte host cell receptor for Plasmodium falciparum sporozoite invasion
Understanding the liver stage invasion and development of Plasmodium falciparum parasites is difficult due to limitations in current methodologies, namely, a hepatocyte cell line that supports the invasion of sporozoites. In this work we seek to develop and characterize a subclone of the HC-04 cell ...
ORGANISM(S): Homo sapiens 
2019-03-02 | E-MTAB-6919 | biostudies-arrayexpress
ProteomicsThe target proteins phosphoglycerate kinase 2 (PGK2), glycerol-3-phosphate dehydrogenase (GPD2)GPD2 and glucose-6-phosphate isomerase (GPI) were screened by combining transcriptome, proteomics and reverse docking, then, we. We detected the binding constant of the active compound using microscale thermophoresis (MST). It was found that esculetin bound well with three potential target proteins.
The results of this study demonstrated that esculetin can affect the glucose metabolism by binding to glycolytic proteins, thus playing an anti-tumor role, and the pathway comprising these proteins which have direct interactions are a potential novel targets for tumor treatment by esculetin.
ORGANISM(S): Homo sapiens (Human) 
2020-01-20 | PXD017062 | Pride
Lc-msms Hepg2 
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