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UnknownA short region upstream of the yeast vacuolar Qa-SNARE heptad-repeats promotes membrane fusion through enhanced SNARE complex assembly.
Not available
S-EPMC5555656 | biostudies-literature
UnknownBinding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein.
Not available
S-EPMC2806771 | biostudies-literature
ProteomicsMIR sequences recruit zinc finger protein ZNF768 to expressed genes
Mammalian-wide interspersed repeats (MIRs) are retrotransposed elements of mammalian genomes. Here we report the specific binding of zinc finger protein ZNF768 to the sequence motif GCTGTGTG (N20) CCTCTCTG in the core region of MIRs. ZNF768 binding is preferentially associated with euchromatin and p...
ORGANISM(S): Homo sapiens (Human) 
2018-10-29 | PXD010831 | Pride
Heptad-repeats Elongator Mammalian interspersed repeats Gene regulation Zinc finger protein Placentalia 
UnknownComplementary interhelical interactions between three buried Glu-Lys pairs within three heptad repeats are essential for Hec1-Nuf2 heterodimerization and mitotic progression.
Not available
S-EPMC3843055 | biostudies-literature
ProteomicsHeptad-specific phosphorylation of RNA polymerase II CTD
The carboxy-terminal domain (CTD) of RNA polymerase II (Pol II) consists of heptad repeats with the consensus motif Y1-S2-P3-T4-S5-P6-S7. Dynamic phosphorylation of the CTD coordinates Pol II progression through the transcription cycle. Monoclonal antibodies have been used to study in vivo the poten...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2016-01-25 | PXD003159 | Pride
Pol ii ctd  ctd heptads  ctd phosphosites  lc-ms/ms 
UnknownKaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion.
Not available
S-EPMC10289257 | biostudies-literature
GenomicsSite-specific methylation and acetylation of lysine residues in the C-terminal domain (CTD) of RNA polymerase II
Dynamic modification of the carboxy-terminal domain (CTD) of RNA polymerase II (RNAPII) regulates transcription-coupled processes in eukaryotes. The CTD in mammals is composed of 52 heptad-repeats with the consensus sequence Y1-S2-P3-T4-S5-P6-S7. Repeats in the distal part of CTD deviate from the co...
ORGANISM(S): Homo sapiens 
2015-12-01 | GSE72698 | GEO
GenomicsThreonine-4 of Mammalian RNA Polymerase II CTD is Targeted by Polo-like Kinase-3 and Required for Transcriptional Elongation
Eukaryotic RNA polymerase II (Pol II) has evolved an array of heptad repeats with the consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 at the carboxy-terminal domain (CTD) of the large subunit (Rpb1). Differential phosphorylation of Ser2, Ser5, and Ser7 in the 5M-bM-^@M-^Y and 3M-bM-^@M-^Y regi...
ORGANISM(S): Homo sapiens 
2012-06-04 | E-GEOD-37519 | biostudies-arrayexpress
UnknownTargeting heptad repeats and fusion peptide: nanoparticle vaccine elicits mucosal immune response against SARS-CoV-2 variants
Not available
S-EPMC12225090 | biostudies-literature
UnknownTransient lipid-bound states of spike protein heptad repeats provide insights into SARS-CoV-2 membrane fusion.
Not available
S-EPMC8500521 | biostudies-literature
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