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ProteomicsTumor immune evasion mediated through IRGQ-directed autophagy
SurfaceOME of IRGQ WT and KO 8988T cells under basal conditions
ORGANISM(S): Homo sapiens (Human) 
2024-11-01 | PXD045259 | Pride
Human 
ProteomicsTumor immune evasion through IRGQ-directed autophagy
interactome of endogenous IRGQ during basal and autophagy-inducing conditions
ORGANISM(S): Homo sapiens (Human) 
2024-11-01 | PXD045117 | Pride
Human 
ProteomicsThe autophagy receptor SQSTM1/p62 is a restriction factor of HCMV infection
Background: Intrinsic defence mechanisms are pivotal host strategies to restrict viruses already at early stages of their infection. Here we addressed the question how the autophagy receptor sequestome 1 (SQSTM1/p62, herein termed p62) interfered with human cytomegalovirus (HCMV) infection. (2) Meth...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus sp. 
2025-05-13 | PXD055196 | Pride
Human cytomegalovirus  autophagy receptor  sqstm1/p62  optineurin  host cell defence 
ProteomicsThe autophagy receptor SQSTM1/p62 is a restriction factor of HCMV infection
(1) Background: Intrinsic defence mechanisms are pivotal host strategies to restrict viruses already at early stages of their infection. Here we addressed the question how the autophagy receptor sequestome 1 (SQSTM1/p62, herein termed p62) interfered with human cytomegalovirus (HCMV) infection. (2) ...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2025-05-07 | PXD055194 | Pride
Human cytomegalovirus  autophagy receptor  sqstm1/p62  optineurin  host cell defence 
ProteomicsThe autophagy receptor SQSTM1/p62 is a restriction factor of HCMV infection
Background: Intrinsic defence mechanisms are pivotal host strategies to restrict viruses already at early stages of their infection. Here we addressed the question how the autophagy receptor sequestome 1 (SQSTM1/p62, herein termed p62) interfered with human cytomegalovirus (HCMV) infection. (2) Meth...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055195 | Pride
Human cytomegalovirus  autophagy receptor  sqstm1/p62  optineurin  host cell defence 
ProteomicsProteome after 3MB-PP1 treatment
The human cytomegalovirus (HCMV) is a member of the beta-herpesvirus family and inflicts life-long latent infections in its hosts. HCMV has been shown to manipulate and dysregulate many cellular processes. On major interactor with the cellular host is the viral kinase pUL97. The UL97 gene is essenti...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036455 | Pride
Human Tmt 
ProteomicsIRGQ-GABARAPL2 complex interactome
GABARAPL2 is the only hATG8 able to fit in the LIR1-G1 loop pocket of IRGQ. To further dissect this striking evolutionary specificity, we queried the interactome of the IRGQ-GABARAPL2 complex with proteomics by using the Venus complementation affinity purification (BiCAP) method.
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD066671 | Pride
Irgq Autophagy Gabarapl2 
ProteomicsGABARAP-L2 WT, S87/88D or A interactomes
TBK1 phosphorylates GABARAP-L2 S87/88. In order to test if this phosphomimetic mutation in GABARAP-L2 changes its binding to other proteins a mass spectrometry based interactome study was performed.
ORGANISM(S): Homo sapiens (Human) 
2019-11-06 | PXD015155 | Pride
Gabarap-l2 
Proteomicsendogenous TBK1-mediated GABARAP-L2 and LC3C phosphorylation site identification
In order to identify TBK1-mediated GABARAP-L2 and LC3C phosphorylation sites, cells were treated with TBK1 or control siRNA and TBK1 kinase activity was induced by treatment with CCCP.
ORGANISM(S): Homo sapiens (Human) 
2019-11-06 | PXD015077 | Pride
Lc3c Tbk1 Gabarap-l2 
ProteomicsTBK1-mediated phosphorylation sites of ATG8s in vitro
Identification of LC3 family proteins phoshorylation sites mediated by TBK1
ORGANISM(S): Homo sapiens (Human) 
2019-11-06 | PXD015065 | Pride
Lc3c Tbk1 Gabarap-l2 
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