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TranscriptomicsAsporin is Expressed at Higher Levels in the More Degenerate Human Intervertebral Disc Tissue
Asporin, also known as periodontal ligament-associated protein 1 (PLAP1), is a member of the family of small leucine-rich proteoglycan (SLRP) family. It is present within the cartilage extracellular matrix (ECM), and is reported have a genetic association with osteoarthritis. Its D14 allele has rec...
ORGANISM(S): Homo sapiens 
2009-03-24 | E-GEOD-15227 | biostudies-arrayexpress
TranscriptomicsNeurotrophin NT3 promotes ovarian primordial to primary follicle transition
Neurotrophins are growth factors that are known to have a role in promoting cell survival and differentiation. The focus of the current study is to examine the role of neurotrophins in regulating ovarian primordial follicle development. Ovaries from 4-day old rats were placed into organ culture and ...
ORGANISM(S): Rattus norvegicus 
2010-02-21 | E-GEOD-20358 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse bipotential embryonic liver cells to identify liver progenitor cell surface markers (430)
The ability to purify to homogeneity a population of hepatic progenitor cells from adult liver is critical for their characterization prior to any therapeutic application. As a step in this direction, we have utilized gene profiling of a bipotential liver cell line from dpc 14 mouse embryonic liver...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6957 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse bipotential embryonic liver cells to identify liver progenitor cell surface markers (430A)
The ability to purify to homogeneity a population of hepatic progenitor cells from adult liver is critical for their characterization prior to any therapeutic application. As a step in this direction, we have utilized gene profiling of a bipotential liver cell line from dpc 14 mouse embryonic liver...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6942 | biostudies-arrayexpress
TranscriptomicsStau2 RIP-Chip in Mouse E13-14 Cortex
The double-stranded RNA binding protein Staufen2 (Stau2) is asymmetrically localized and segregated during asymmetric cell divisions in the developing mouse cortex and promotes intermediate progenitor cell fate. We carry out RNA immunoprecipitation with a Stau2 specific antibody, followed by microar...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-38222 | biostudies-arrayexpress
TranscriptomicsGene Expression Data from Senescent vs Non-senescent Cells in the in Vivo Human Annulus
The presence of senescent cells in the aging/degenerating human disc is now well-recognized. Senescent cells are viable, cannot divide, remain metabolically active and accumulate within the disc over time. Molecular analysis of senescent cells in tissue, however, offers a special challenge since the...
ORGANISM(S): Homo sapiens 
2009-07-15 | E-GEOD-17077 | biostudies-arrayexpress
TranscriptomicsIL-1 Exposure Significantly increases gene expression of BDNF, NTF3 and NRP2 as well as NGF Production in Human Annulus Cells
Although the degenerating disc is considered to be the key source of pain in patients with low back pain, the relationship between disc cells, nerves, and pain production is poorly understood. Neurotrophins are signaling molecules involved in the survival, differentiation, migration, and neurite ou...
ORGANISM(S): Homo sapiens 
2012-06-26 | E-GEOD-27494 | biostudies-arrayexpress
TranscriptomicsPlatform comparison and transcription profiling of mixed tissue RNA samples formulated to contain different ratios of RNA for each of four rat tissues (brain, liver, kidney, and testes) on Affymetrix RAE230A, CodeLink UniSet Rat I, and Agilent G4130A rat oligonucleotide arrays
This experiment is a test of a reagent that can provide a basis for performance assessments on Affymetrix RAE230A, CodeLink UniSet Rat I, and Agilent G4130A rat oligonucleotide arrays. The reagent is a set of two mixed tissue RNA samples formulated to contain different ratios of RNA for each of f...
ORGANISM(S): Rattus norvegicus 
2010-03-30 | E-TABM-16 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq for undifferentiated spermatogonia from the testes of control, aged and busulfan-treated C57BL/6 mice
Samples were prepared from 100 GFRa1-GFP positive, Miwi2-tdTom negative and 100 GFRa1-GFP negative, Miwi2-tdTom positive cells that were sorted with FACS. cDNA libraries were prepared with the SMARTseq2 protocol. Adult, control samples had four biological replicates while the aged and busulfan-trea...
ORGANISM(S): Mus musculus 
2022-02-28 | E-MTAB-9238 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq for undifferentiated spermatogonia from the testes of control, aged and busulfan-treated C57BL/6 mice
GFRa1-GFP positive, Miwi2-tdTom negative and GFRa1-GFP negative, Miwi2-tdTom positive single cells from the testes of 2 adult, 2 aged and 3 busulfan-treated mice were sorted with FACS and cDNA libraries prepared with the SMARTseq2 protocol. Single-cell libraries were sequenced
ORGANISM(S): Mus musculus 
2022-02-28 | E-MTAB-9239 | biostudies-arrayexpress
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