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UnknownQuantitative vascular pathology and phenotyping familial and sporadic cerebral small vessel diseases.
Not available
S-EPMC8029230 | biostudies-literature
UnknownNeuropathology and genetics of cerebroretinal vasculopathies.
Not available
S-EPMC8029267 | biostudies-literature
UnknownNew roles for the major human 3'-5' exonuclease TREX1 in human disease.
Not available
S-EPMC2825026 | biostudies-literature
UnknownMonogenic Causes of Strokes.
Not available
S-EPMC8700771 | biostudies-literature
ProteomicsInherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans
Age-related microangiopathy, also known as small vessel disease (SVD), causes damage to the liver, brain, kidney and retina. Based on the DNA damage theory of aging, we reasoned that genomic instability may underlie an SVD caused by dominant C-terminal variants in TREX1, the most abundant 3’-5’ DNA ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-30 | PXD051905 | Pride
Brca1 Retinal vasculopathy with cerebral leukoencephalopathy Cerebroretinal vasculopathy Rvcl-s Rvcl Trex1 Interferon Inflamm-aging Herns Crv Dementia Dna damage response Small vessel disease Vasculopathy 
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