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TranscriptomicsBulk RNA-seq from Trex1 KO in heart
Bulk RNA-seq data for Trex1 WT and KO mice from the heart. Used for manuscript in submission at Science Advances.
ORGANISM(S): Mus musculus 
2026-03-25 | E-MTAB-16524 | biostudies-arrayexpress
TranscriptomicsscRNA-seq from Trex1 KO in heart
Single-cell RNA-seq data for Trex1 WT and KO mice from the heart. Used for manuscript in submission at Science Advances.
ORGANISM(S): Mus musculus 
2026-03-25 | E-MTAB-16525 | biostudies-arrayexpress
TranscriptomicsscRNA-seq from Trex1 KO in tumor
Single-cell RNA-seq data for Trex1 WT and KO mice from the tumor. Used for manuscript in submission at Science Advances.
ORGANISM(S): Mus musculus 
2026-03-25 | E-MTAB-16526 | biostudies-arrayexpress
ProteomicsInherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans
Age-related microangiopathy, also known as small vessel disease (SVD), causes damage to the liver, brain, kidney and retina. Based on the DNA damage theory of aging, we reasoned that genomic instability may underlie an SVD caused by dominant C-terminal variants in TREX1, the most abundant 3’-5’ DNA ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-30 | PXD051905 | Pride
Brca1 Retinal vasculopathy with cerebral leukoencephalopathy Cerebroretinal vasculopathy Rvcl-s Rvcl Trex1 Interferon Inflamm-aging Herns Crv Dementia Dna damage response Small vessel disease Vasculopathy 
TranscriptomicsImpaired DNA damage metabolism promotes autoimmunity in TREX1 deficiencyÂ
Constitutive low level DNA damage is linked to innate immune activation. Hierarchical clustering of over 9000 transcripts revealed remarkably similar profiles in a patient with lupus erythematosus and a patient with AGS with up-regulation of genes involved in DNA damage signaling, p53-inducible gene...
ORGANISM(S): Homo sapiens 
2016-05-30 | E-GEOD-59233 | biostudies-arrayexpress
ProteomicsER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei
Micronuclei are membrane-encapsulated nuclear aberrations that form following cell division errors. Micronuclear membrane collapse results in DNA damage and cGAS-STING activation. TREX1 inhibits cGAS activation by degrading micronuclear DNA. Aside from a dependency on ER-tethering, the mechanisms di...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD062583 | Pride
Chromosomal instability Micronuclei Sting Chromothripsis Trex1 Cgas 
GenomicsTrex1 knock out in cancer cell lines
Trex1 knock out in cancer cell lines
PRJEB72744 | ENA
GenomicsscRNA-seq from Trex1 KO in heart
scRNA-seq from Trex1 KO in heart
PRJEB106527 | ENA
GenomicsscRNA-seq from Trex1 KO in tumor
scRNA-seq from Trex1 KO in tumor
PRJEB106528 | ENA
TranscriptomicsLoss of Trex1 in dendritic cells is sufficient to trigger systemic autoimmunity
Biallelic defects of the gene encoding for the intracellular enzyme 3’ repair exonuclease (Trex)1 cause Aicardi-Goutières syndrome (AGS), a rare monogenic, lupus-like autoimmune disease, while heterozygous Trex1 loss of function alleles are associated with systemic lupus erythematosus (SLE). Trex...
ORGANISM(S): Mus musculus 
2016-08-01 | E-GEOD-77693 | biostudies-arrayexpress
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