Micronuclei - OmicsDI

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Characterization of extracellular micronuclei

Microglia, resident immune cells in the central nervous system, undergo morphological and functional changes in response to signals from the local environment and mature into various homeostatic states. However, niche signals underlying microglial differentiation and maturation remain unknown. Here,...

ORGANISM(S): Mus musculus (Mouse)

2024-12-29 | PXD056089 | Pride

Primary neurons Micronuclei

A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements

Chromosomal instability (CIN) generates micronuclei, aberrant extranuclear structures that catalyze the acquisition of complex chromosomal rearrangements present in cancer. Micronuclei are characterized by persistent DNA damage and catastrophic nuclear envelope collapse, exposing DNA to the cytoplas...

ORGANISM(S): Homo sapiens (Human)

2024-09-02 | PXD052675 | Pride

Chromosome missegregation Micronuclei P62

ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei

Micronuclei are membrane-encapsulated nuclear aberrations that form following cell division errors. Micronuclear membrane collapse results in DNA damage and cGAS-STING activation. TREX1 inhibits cGAS activation by degrading micronuclear DNA. Aside from a dependency on ER-tethering, the mechanisms di...

ORGANISM(S): Homo sapiens (Human)

2026-03-09 | PXD062583 | Pride

Chromosomal instability Micronuclei Sting Chromothripsis Trex1 Cgas

Epigenetic dysregulation from chromosomal transit in micronuclei [ATAC-Seq]

PRJNA885433 | ENA

Epigenetic dysregulation from chromosomal transit in micronuclei [4T1 MN ATAC-Seq]

PRJNA774660 | ENA

Epigenetic dysregulation from chromosomal transit in micronuclei [MN CUT&RUN]

PRJNA883723 | ENA

Epigenetic dysregulation from chromosomal transit in micronuclei [Chr4 ATAC-seq]

PRJNA884311 | ENA

Epigenetic dysregulation from chromosomal transit in micronuclei [MMCT ATAC-seq]