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UnknownPrevalence of and risk factors for anal human papillomavirus infection among young healthy women in Costa Rica.

Background

Anal cancer is caused by human papillomavirus (HPV), yet little is known about anal HPV infection among healthy young women.

Methods

A total of 2017 sexually active women in the control arm of an HPV-16/18 vaccine trial had a single anal specimen collected by a clinician at...
S-EPMC3499109 | biostudies-literature
UnknownEffect of Direct Transportation to Thrombectomy-Capable Center vs Local Stroke Center on Neurological Outcomes in Patients With Suspected Large-Vessel Occlusion Stroke in Nonurban Areas: The RACECAT Randomized Clinical Trial.

Importance

In nonurban areas with limited access to thrombectomy-capable centers, optimal prehospital transport strategies in patients with suspected large-vessel occlusion stroke are unknown.

Objective

To determine whether, in nonurban areas, direct transport to a thrombectomy-capabl...
S-EPMC9073661 | biostudies-literature
UnknownClinical practice selectively follows acute appendicitis guidelines.

Introduction

Acute appendicitis is a common surgical emergency, and the standard approach to diagnosis and management has been codified in several practice guidelines. Adherence to these guidelines provides insight into independent surgical practice patterns and institutional resource constr...
S-EPMC9888346 | biostudies-literature
UnknownSurgical management of acute appendicitis during the European COVID-19 second wave: safe and effective.

Introduction

The COVID-19 (SARS-CoV-2) pandemic drove acute care surgeons to pivot from long established practice patterns. Early safety concerns regarding increased postoperative complication risk in those with active COVID infection promoted antibiotic-driven non-operative therapy for sele...
S-EPMC9851576 | biostudies-literature
UnknownTechniques for mesoappendix transection and appendix resection: insights from the ESTES SnapAppy study.

Introduction

Surgically managed appendicitis exhibits great heterogeneity in techniques for mesoappendix transection and appendix amputation from its base. It is unclear whether a particular surgical technique provides outcome benefit or reduces complications.

Material and methods

We ...
S-EPMC9925585 | biostudies-literature
UnknownDevelopment and validation of a prediction model for 30-day mortality in hospitalised patients with COVID-19: the COVID-19 SEIMC score.

Objective

To develop and validate a prediction model of mortality in patients with COVID-19 attending hospital emergency rooms.

Design

Multivariable prognostic prediction model.

Setting

127 Spanish hospitals.

Participants

Derivation (DC) and external validation (VC) coho...
S-EPMC7908055 | biostudies-literature
UnknownGWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.
Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patie...
S-EPMC10208981 | biostudies-literature
UnknownStoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort.

Objective

To develop and validate a prediction model (STOMA score) for 1-year stoma-free survival in patients with rectal cancer (RC) with anastomotic leakage (AL).

Background

AL after RC resection often results in a permanent stoma.

Methods

This international retrospective coh...
S-EPMC10549897 | biostudies-literature
UnknownColorectal-vaginal fistula after rectal cancer resection: international comparative cohort study of characteristics and treatment.
Not available
S-EPMC12624856 | biostudies-literature
UnknownStoma-free survival after anastomotic leak following rectal cancer resection: worldwide cohort of 2470 patients.

Background

The optimal treatment of anastomotic leak after rectal cancer resection is unclear. This worldwide cohort study aimed to provide an overview of four treatment strategies applied.

Methods

Patients from 216 centres and 45 countries with anastomotic leak after rectal cancer re...
S-EPMC10638542 | biostudies-literature
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