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OtherExecutioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart.
Data from PeptideAtlas, [[http://www.peptideatlas.org/PASS/PASS00689 PASS00689]]. File: JAL_DanSanc_Hrt_iTRAQ_Fr6.mzml. Published as part of PLoS One. 2015 Jun 29;10(6):e0131411 . From the Abstract: {{i}} Executioner caspase-3 and -7 are proteases promoting cell death but non-apoptotic roles are be...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320017677 | GPMDB
TranscriptomicsTranscription profiling of injured mouse hearts from C57Bl/6 and MRL sampled at 3 time points to investigate the regenerative capacity of the mammalian heart
Previous studies have suggested that the heart may be capable of limited repair and regeneration in response to a focal injury while other studies indicate that the mammalian heart has no regenerative capacity. To further explore this issue, we performed a series of superficial and transmural myocar...
ORGANISM(S): Mus musculus 
2007-11-23 | E-GEOD-4710 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways
The mammalian heart has poor regenerative capacity following injury. In contrast, certain lower vertebrates such as zebrafish retain a robust capacity for regeneration into adult life. Here we use an integrated approach to identify evolutionary conserved regenerative miRNA-dependant regulatory circu...
ORGANISM(S): Danio rerio 
2016-02-18 | E-GEOD-51018 | biostudies-arrayexpress
TranscriptomicsHost microbiota constantly control maturation and function of microglia in the central nervous system (part 2)
As tissue macrophages of the central nervous system (CNS), microglia are critically involved in diseases of the CNS. However, it remains unknown what controls their maturation and activation under homeostatic conditions. Here we reveal significant contributions of the host microbiota to microglia ho...
ORGANISM(S): Mus musculus 
2015-05-25 | E-GEOD-67857 | biostudies-arrayexpress
ProteomicsHeart surfaceome profiling using biotin capture
Cell surface proteins (surfaceome) represent key signalling and interaction molecules for therapeutic targeting, biomarker profiling, and cellular phenotyping. Understanding the surfaceome of complex tissues including the heart is essential to investigate membrane composition and function in physiol...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000095912 | MassIVE
TranscriptomicsTranscription profiling of rat cardiac injury: a potential link to air pollution mortality?
Zinc (Zn) is a major elemental component of respirable ambient particulate matter (PM) detected often at alarming levels in urban air. Exposure to PM has been widely associated with increased cardiovascular morbidity and mortality, however, it is not known what components or sources of PM are causat...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-6541 | biostudies-arrayexpress
ProteomicsRegion and cell-type resolved quantitative proteomic map of the human heart and its application to atrial fibrillation
The heart is a central human organ and its diseases are the leading cause of death worldwide, but an in-depth knowledge of the identity and quantity of its constituent proteins is still lacking. Here we determine the healthy human heart proteome by measuring 16 anatomical regions and three major car...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-10-03 | MSV000084410 | MassIVE
TranscriptomicsSingle cell RNA-Seq of the mouse heart in response to chronic stress
We characterized single-cell transcriptional profiles of heart ventricles of C57BL/6J female and male mice subjected to a chronic stress, two weeks of continuous administration of Angiotensin II. The cell preparation we sequenced consisted of metabolically active, nucleated non-myocyte cells which ...
ORGANISM(S): Mus musculus 
2020-11-24 | E-MTAB-8810 | biostudies-arrayexpress
TranscriptomicsA long noncoding RNA protects the heart from pathological hypertrophy
The role of long noncoding RNA (lncRNA) in adult hearts is unknown; also unclear is how lncRNA modulates nucleosome remodelling. An estimated 70% of mouse genes undergo antisense transcription1, including myosin heavy chain 7 (Myh7), which encodes molecular motor proteins for heart contraction2. Her...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-49716 | biostudies-arrayexpress
Transcriptomicsmicroarray of healthy heart tissue of mouse (BALB/c nude female mice) after proton-beam treatment to cure breast cancer
Proton irradiation: 2, 6 and 9 Gy + untreated controls Times after irradiation: 3 and 10 days Associated pubblication: Sala, C.; Tarozzi, M.; Simonetti, G.; Pazzaglia, M.; Cammarata, F.P.; Russo, G.; Acquaviva, R.; Cirrone, G.A.P.; Petringa, G.; Catalano, R.; et al. Impact on the Transcriptome of ...
ORGANISM(S): Mus musculus 
2024-04-30 | E-MTAB-14006 | biostudies-arrayexpress
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