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ProteomicsAKT isoform specific signaling
Phosphoproteome analysis of HL-1 cardiomyocytes carrying AKT1 or AKT2 isoform specific knock down, respectively. Six biological replicates were analysed. Cells were grown until reaching 90 % confluency, starved for 50 minutes followed by stimulation with 200 nM insulin for 10 minutes. In solution st...
ORGANISM(S): Mus musculus (Mouse) 
2014-08-28 | PXD000268 | Pride
Ltq-orbitrap Phosphoproteome Akt Hl-1 cardiac myocytes 
TranscriptomicsDetailed transcriptomics analysis of the effect of the PPARalpha agonist Wy14,643 on gene regulation in the murine heart
Fatty acids comprise the primary energy source for the heart and are mainly taken up via hydrolysis of circulating triglyceride-rich lipoproteins. While most of the fatty acids entering the cardiomyocyte are oxidized, a small portion is involved in altering gene transcription to modulate cardiometab...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-30553 | biostudies-arrayexpress
OtherAKT1 AND AKT2 INDUCE DISTINCT PHOSPHORYLATION PATTERNS IN HL-1 CARDIAC MYOCYTES.
Data from ProteomeXchange, PXD ID: PXD000268. Experiment: DML2, file: folder summary. Published as part of J Proteome Res. 2014 Aug 27 . From the Abstract: {{i}} ... To gain more insight into AKT isoform specific signaling at the molecular level we investigated the phosphoproteome of HL-1 cardiomyo...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32310003337 | GPMDB
Resource Reanalysis 
ProteomicsMouse Heart SS31 Targeted Proteomics
The S-glutathionylation and phosphorylation proteomes of mouse hearts were analyzed using shotgun proteomics methods in order to assess the effects of aging and the ability of mitochondrion-targeted drug SS-31 to reverse age-related changes. There was a nearly universal increase in S-gluthationylati...
ORGANISM(S): Mus Musculus 
2022-03-16 | PXD024247 | panorama
TranscriptomicsEnvironmentally Induced Epigenetic Transgenerational Inheritance of Somatic Transcriptomes
Environmentally induced epigenetic transgenerational inheritance of adult onset disease involves a variety of phenotypic changes suggesting a general alteration in genome activity. Investigation of eleven different tissue transcriptomes in male and female F3 generation vinclozolin versus control l...
ORGANISM(S): Rattus norvegicus 
2012-06-30 | E-GEOD-35839 | biostudies-arrayexpress
TranscriptomicsPupylated proteins in Corynebacterium glutamicum revealed by MudPIT analysis
In a manner similar to ubiquitin, the prokaryotic ubiquitin-like protein (Pup) has been shown to target proteins for degradation via the proteasome in mycobacteria. However, not all actinobacteria possessing the Pup protein also harbor a proteasome, suggesting fates for pupylated proteins other than...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2014-06-24 | E-GEOD-48038 | biostudies-arrayexpress
GenomicsChIP-seq of Ezh2 and H3K27me3 in E12.5 heart apex
Ezh2 and H3K27me3 binding sites in E12.5 heart apex PRC2 binding sites in wild type cardiomyocytes
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-29994 | biostudies-arrayexpress
TranscriptomicsGene expression and genotype in normal heart
Genome-wide association studies have identified a small region at chromosome 9p21.3 strongly associated with coronary heart disease risk. The region contains no protein-coding genes and the mechanism underlying its association with heart disease is unknown. We investigated associations between rs133...
ORGANISM(S): Homo sapiens 
2012-07-03 | E-GEOD-22253 | biostudies-arrayexpress
ProteomicsComprehensive respiratory phenomics across multiple models of mitochondrial protein hyperacylation reveals a paradoxically marginal impact on bioenergetics
Acyl CoA metabolites derived from catabolism of carbon fuels can react with lysine residues of mitochondrial proteins, giving rise to a large family of post-translation modifications (PTMs). Mass spectrometry-based detection of thousands of acyl-PTMs scattered throughout the proteome has established...
ORGANISM(S): Mus Musculus (mouse) 
2019-02-07 | PXD011375 | JPOST Repository
GenomicsEzh2 and H3K27me3 in cardiomyocytes
This SuperSeries is composed of the following subset Series: GSE29992: Genome-wide profiling of E12.5 cardiomyocytes RNA expression in both hetozygeous control and mutant GSE29994: ChIP-seq of Ezh2 and H3K27me3 in E12.5 heart apex Refer to individual Series
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-29997 | biostudies-arrayexpress
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