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ProteomicsCX-MS of Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore
Kinetochores form the link between chromosomes and microtubules of the mitotic spindle. The heterodecameric Dam1 complex (Dam1c) is a major component of the S. cerevisiae outer kinetochore, assembling into 3 MDa-sized microtubule-embracing rings, but how ring assembly is specifically initiated at ki...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-06-28 | PXD026935 | Pride
Mass spectrometry Kinetochore Chemical cross-linking 
ProteomicsThe COMA complex plays a role in positioning Ipl1 activity proximal to Cse4 nucleosomes
Kinetochores are macromolecular protein complexes that ensure accurate chromosome segregation by linking chromosomes to spindle microtubules and integrating safeguard mechanisms. In yeast, the inner kinetochore, also known as Constitutive Centromere Associated Network (CCAN), is specifically establi...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-04-12 | PXD011236 | Pride
Kinetochore  centromere  mtw  mif2  cross-linking  yeast 
ProteomicsAOCM-CPC - Kinetochores are macromolecular protein complexes that ensure accurate chromosome segregation by linking chromosomes to spindle microtubules and integrating safeguard mechanisms
Kinetochores are macromolecular protein complexes that ensure accurate chromosome segregation by linking chromosomes to spindle microtubules and integrating safeguard mechanisms. In yeast, the inner kinetochore, also known as Constitutive Centromere Associated Network (CCAN), is specifically establi...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-04-12 | PXD011235 | Pride
Kinetochore  cpc  coma  cross-linking 
ProteomicsBeyond Pattern Recognition: TLR2 Promotes Chemotaxis, Cell Adhesion and Migration in THP-1 Cells
The interaction between monocytes and endothelial cells in inflammation is central to chemoattraction, adhesion, and transendothelial migration. Key players such as selectins and their ligands, integrins and other adhesion molecules and their function in these processes are well studied. Toll-like r...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD041819 | Pride
Cell adhesion  cell migration Toll-like receptor 2  chemotaxis Thp-1 
ProteomicsComparative and temporal characterization of LPS and blue light induced TLR4 signal transduction and gene expression in optogenetically manipulated endothelial cells
In endothelial cells (ECs), stimulation of Toll-like receptor 4 (TLR4) by the endotoxin lipopolysaccharide (LPS) induces the release of diverse pro-inflammatory mediators beneficial in controlling bacterial infections. However, their systemic secretion is a main driver of sepsis and chronic inflamma...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038764 | Pride
Lipopolysaccharide Chemotaxis Endothelial cells Mass spectrometry based proteomics Transmigration Toll-like receptor 4 Optogenetic control Pro-inflammatory proteins 
ProteomicsSeeding the meiotic DNA break machinery and initiating recombination on chromosome axes
Recombination-mediated linking of homologous chromosomes is a unique meiotic feature that enables the halving of chromosomal ploidy in sexual life cycles. Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) that are generated by focal multi-protein clusters that condense...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-23 | PXD042221 | Pride
Iho1 Phosphorylation 
ProteomicsImpact of PD1/PD-L1 Inhibition on Bone Remodeling: a Prospective Clinical Study and ex-vivo Validation.
Background Skeletal morbidity in cancer patients has a major impact on quality of life and preserving bone health while improving outcomes is an important goal of modern antitumor treatment strategies. Despite their widespread use in early disease stages, the effects of immune-checkpoint inhibitors ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD047604 | Pride
Bone remodeling  immune-checkpoint inhibitors  3d model  data-independent acquisition 
ProteomicsHs_U2OS_Control_Samples_Velos
Hs U2OS NON-Synchronized Cell Samples Velos
ORGANISM(S): Homo Sapiens (human) 
2011-12-31 | PAe003660 | PeptideAtlas
ProteomicsHs_U2OS_SN_Samples_Velos
Hs U2OS Synchronized Cell Samples Velos
ORGANISM(S): Homo Sapiens (human) 
2011-12-31 | PAe003655 | PeptideAtlas
UnknownMulticentric investigation on the safety, feasibility and usability of the ABLE lower-limb robotic exoskeleton for individuals with spinal cord injury: a framework towards the standardisation of clinical evaluations.
Not available
S-EPMC10091314 | biostudies-literature
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