Iho1 - OmicsDI

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Lab affiliation

Institute of Physiological Chemistry, Medical Faculty of TU Dresden, Fiedlerstrasse 42 01307 Dresden, Germany (1)
Institute Krems Bioanalytics, IMC University of Applied Sciences, 3500 Krems, Austria (1)

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Tags

xref:PubMed:30853435 (1)

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Seeding the meiotic DNA break machinery and initiating recombination on chromosome axes

Recombination-mediated linking of homologous chromosomes is a unique meiotic feature that enables the halving of chromosomal ploidy in sexual life cycles. Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) that are generated by focal multi-protein clusters that condense...

ORGANISM(S): Mus musculus (Mouse)

2024-02-23 | PXD042221 | Pride

Iho1 Phosphorylation

Seeding the meiotic DNA break machinery and initiating recombination on chromosome axes

ORGANISM(S): Mus musculus (Mouse)

2024-02-23 | PXD042179 | Pride

Biochemical assay Meiotic recombination Iho1-hormad1 Protein phosphorylation Label-free quantitative mass spectrometry Meiosis

Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice.

Not available

S-EPMC5089853 | biostudies-literature

Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation

Not available

S-SCDT-10_15252-EMBJ_2023113866 | biostudies-other

Principles of chromosome organization for meiotic recombination

In meiotic cells, chromosomes are organized as chromatin loop arrays anchored to a protein axis. This organization is essential to regulate meiotic recombination, from DNA double-strand break (DSB) formation to their repair. In mammals, it is unknown how chromatin loops are organized along the genom...

ORGANISM(S): Mus musculus

2024-04-23 | GSE262343 | GEO

Seeding the meiotic DNA break machinery and initiating recombination on chromosome axes.

Not available

S-EPMC10997794 | biostudies-literature

Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice.

Not available

S-EPMC7969012 | biostudies-literature

Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4.

Not available

S-EPMC6288613 | biostudies-literature

Sycp1 Is Not Required for Subtelomeric DNA Double-Strand Breaks but Is Required for Homologous Alignment in Zebrafish Spermatocytes.