Sort   by:  
 Page size 
ProteomicsSeeding the meiotic DNA break machinery and initiating recombination on chromosome axes
Recombination-mediated linking of homologous chromosomes is a unique meiotic feature that enables the halving of chromosomal ploidy in sexual life cycles. Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) that are generated by focal multi-protein clusters that condense...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-23 | PXD042179 | Pride
Biochemical assay Meiotic recombination Iho1-hormad1 Protein phosphorylation Label-free quantitative mass spectrometry Meiosis 
ProteomicsSeeding the meiotic DNA break machinery and initiating recombination on chromosome axes
Recombination-mediated linking of homologous chromosomes is a unique meiotic feature that enables the halving of chromosomal ploidy in sexual life cycles. Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) that are generated by focal multi-protein clusters that condense...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-23 | PXD042221 | Pride
Iho1 Phosphorylation 
GenomicsPrinciples of chromosome organization for meiotic recombination
In meiotic cells, chromosomes are organized as chromatin loop arrays anchored to a protein axis. This organization is essential to regulate meiotic recombination, from DNA double-strand break (DSB) formation to their repair. In mammals, it is unknown how chromatin loops are organized along the genom...
ORGANISM(S): Mus musculus 
2024-04-23 | GSE262343 | GEO
UnknownMeiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice.
Not available
S-EPMC5089853 | biostudies-literature
UnknownSeeding the meiotic DNA break machinery and initiating recombination on chromosome axes.
Not available
S-EPMC10997794 | biostudies-literature
UnknownSCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination.
Not available
S-EPMC9122608 | biostudies-literature
GenomicsPrinciples of chromosome organization for meiotic recombination
Principles of chromosome organization for meiotic recombination
PRJNA1091364 | ENA
UnknownSycp1 Is Not Required for Subtelomeric DNA Double-Strand Breaks but Is Required for Homologous Alignment in Zebrafish Spermatocytes.
Not available
S-EPMC8033029 | biostudies-literature
GenomicsGenome wide map of DMC1 in testis of Stag3-/-, Rec8-/- and Stag3-/-Rec8-/- mice.
During mouse meiosis, DNA double-strand breaks (DSBs) are initiated by SPO11 at recombination hotspots (HSs), activated by PRDM9. Although activated HSs are marked by H3K4me3 and H3K36me3 histone modifications at open chromatin, most of the DSB-initiating and repair proteins are associated with the ...
ORGANISM(S): Mus musculus 
2019-03-07 | GSE112110 | GEO
UnknownPrdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA Double-Strand Break Formation in Mammalian Spermatocytes.
Not available
S-EPMC6544150 | biostudies-literature
Sort   by:  
 Page size