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ProteomicshESCs quantitative proteomic MASS
To understand the potential signaling by which the loss of UBQLN1 leads to telomere damage,we performed quantitative proteomic MASS
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD036642 | Pride
Hescs quantitative proteomic mass 
ProteomicsProteomic investigation of the effect of DAP5 knock-down on human embryonic stem cells
We performed a deep mass-spec analysis to determine DAP5 proteomic signature on human embryonic stem cells (hESCs) by evaluating the steady state proteins level on DAP5-KD and NT control cells.
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-08-10 | PXD030717 | Pride
Human Dap5 Mouse Fibroblasts Escs 
UnknownIdentification of proteins related to epigenetic regulation in the malignant transformation of aberrant karyotypic human embryonic stem cells by quantitative proteomics.
Not available
S-EPMC3895013 | biostudies-literature
ProteomicsQuantitative analysis of redox proteome reveals protein thiol switches regulating fundamental processes in developmental hematopoiesis
Fetal and adult hematopoietic stem and progenitor cells (HSPCs) are characterized by distinct redox homeostasis that may influence their differential cellular behaviour in normal and malignant haematopoiesis. In this work, we have applied a quantitative mass spectrometry-based redox proteomic approa...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD033115 | Pride
Oxidative modifications Oxidative stress Redox proteomics Hydrogen peroxide Human embryonic stem cells 
ProteomicsGeneration and Proteome Profiling of PBMC-originated, iPSCs-derived Corneal Endothelial Cells
Corneal endothelial cells (CECs) are critical to maintaining clarity of the cornea. This study was initiated to develop peripheral blood mononuclear cells (PBMC)-originated induced pluripotent stem cells (iPSCs)-derived CECs. We isolated PBMC and programmed the mononuclear cells to generate iPSCs. S...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD009142 | Pride
Mass-spectrometry Proteome Ipscs-derived corneal endothelial cells Pbmc 
ProteomicsA proteomic roadmap of ribosome heterogeneity during human embryonic stem cell differentiation
Recent findings suggest that the ribosome itself modulates gene expression. However, whether ribosomes change composition across cell types to control cell fate remains unknown. To determine the magnitude of ribosome heterogeneity and its functional contribution to cell fate specification, we measu...
ORGANISM(S): Homo sapiens (Human) 
2022-09-19 | PXD032904 | Pride
Differentiation Ribosome Tandem mass tags (tmt) Human embryonic stem cell 
ProteomicsComprehensive transcriptomic and proteomic characterization of human mesenchymal stem cells reveals source specific cellular markers
Mesenchymal stem cells (MSC) are multipotent cells with great potential in therapy, reflected by more than 500 MSC-based clinical trials registered with the NIH. MSC are derived from multiple tissues but require invasive harvesting and imply donor-to-donor variability. Embryonic stem cell-derived MS...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080827 | MassIVE
ProteomicsHDAC6 inhibition alleviates mitochondrial trafficking in novel models of Charcot-Marie-Tooth Disease Type 2A
Charcot-Marie-Tooth Disease (CMT) is a group of inherited progressive conditions affecting distal motor and sensory neurons, leading to muscle weakness, pain and loss of sensation in limbs. CMT type 2A (CMT2A) is the most common form of axonal CMT and is associated with a more severe clinical manife...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD077751 | Pride
Mitochondria Mitofusin-2 Charcot-marie-tooth disease type 2a 
ProteomicsAdaptation of a commonly used, chemically defined medium for human embryonic stem cells to stable isotope labeling with amino acids in cell culture (SILAC)
Metabolic labeling with stable isotopes is a prominent technique for comparative quantitative proteomics and stable isotope labeling with amino acids in cell culture (SILAC) is the most commonly used approach. SILAC is, however, traditionally limited to simple tissue culture regiments and only rare...
ORGANISM(S): Homo sapiens (Human) 
2013-06-17 | PXD000151 | Pride
Stable isotope labeling by amino acids in cell culture Silac Human embryonic stem cells Hesc 
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