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ProteomicsDrosophila HP1a IP-MS - The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic
Heterochromatin is enriched for characteristic epigenetic factors, including Heterochromatin Protein 1a (HP1a) and is essential for many organismal functions. However, how this nuclear domain is organized and functions is unclear. We extensively investigated heterochromatin protein compostion by bio...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2016-08-18 | PXD003780 | Pride
Heterochromatin protein 1a Drosophila melanogaster 
TranscriptomicsRelics of repeat-induced point mutation direct heterochromatin formation in Neurospora crassa
Both RNAi-dependent and -independent mechanisms have been implicated in the establishment of heterochromatin domains, which may be stabilized by feedback loops involving chromatin proteins and modifications of histones and DNA. Neurospora crassa sports features of heterochromatin found in higher eu...
ORGANISM(S): Neurospora crassa 
2010-05-15 | E-GEOD-12690 | biostudies-arrayexpress
TranscriptomicsP. falciparum Heterochromatin Protein 1 Marks Genomic Loci Linked to Phenotypic Variation of Exported Virulence Factors
Epigenetic processes are the main conductors of phenotypic variation in eukaryotes. The malaria parasite Plasmodium falciparum employs antigenic variation of the major surface antigen PfEMP1, encoded by 60 var genes, to evade acquired immune responses. PfEMP1 also mediates sequestration of infected ...
ORGANISM(S): Plasmodium falciparum 
2010-05-06 | E-GEOD-17029 | biostudies-arrayexpress
GenomicsHeterochromatin remodeling by CDK12 contributes to learning in Drosophila
We describe the epigenetic profiling of the H3K9me2 and HP1a in Drosophila third instar larvae before and after CDK12 depletion by RNA interference (RNAi). Here we show that CDK12 regulates heterochromatin dynamics in Drosophila chromosomes. Depletion of CDK12 induces the increased HP1a and H3K9me2 ...
ORGANISM(S): Drosophila melanogaster 
2015-11-02 | E-GEOD-63011 | biostudies-arrayexpress
TranscriptomicsA conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing [sRNA-seq]
Co-transcriptional RNA processing and surveillance factors mediate heterochromatin formation in fission yeast. In addition to RNAi, RNA elimination machinery including MTREC (Mtl1-Red1 core) and the exosome are involved in facultative heterochromatin assembly, however, the exact mechanisms remain un...
ORGANISM(S): Schizosaccharomyces pombe 
2016-01-05 | E-GEOD-74739 | biostudies-arrayexpress
TranscriptomicsWIP1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation
WIP1 phosphatase is emerging as an important regulator of tumorigenesis, but no unifying mechanistic network has been proposed. Here we found that WIP1 plays a key role in the transcriptional regulation of heterochromatin-associated DNA sequences in germ-line and cancer cells. WIP1 was required for ...
ORGANISM(S): Mus musculus 
2013-10-19 | E-GEOD-46103 | biostudies-arrayexpress
TranscriptomicsSilencing factors induce the elimination of nucleosome-free regions in S. pombe heterochromatin
Abstract: In the yeast S. pombe, multiple chromatin-modifying enzymes are required for heterochromatin formation, yet how their actions alter chromatin structure to block access to DNAby the transcriptional machinery is unknown. We constructed high-resolution nucleosome occupancy maps of heterochrom...
ORGANISM(S): Schizosaccharomyces pombe 
2010-11-24 | E-GEOD-19596 | biostudies-arrayexpress
GenomicsSpecificity, propagation and memory of pericentric heterochromatin in mouse fibroblasts
We assembled a quantitative map for the abundance and interactions of 16 factors related to PCH in living cells and found that stably bound complexes of the histone methyltransferase Suv39h1/2 demarcate the PCH state. From the experimental data we developed a predictive mathematical model that expla...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-58555 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of heterochromatin protein 1 in male and female Drosophila flies
Drosophila heterochromatin protein 1- HP1 is believed to be involved in active transcription, transcriptional gene silencing, and the formation of heterochromatin2-7. However, little is known about the function of HP1 during development. Using a Gal4-induced RNA interference system, we show that con...
ORGANISM(S): Drosophila melanogaster 
2007-08-01 | E-GEOD-3055 | biostudies-arrayexpress
TranscriptomicsHeterochromatin-associated interactions of Drosophila HP1 with dADD1, HIPP1, and repetitive RNAs
We report chromatin-associated protein and RNA interactions of HP1a, indentified by BioTAP-XL mass spectrometry and sequencing. We identify an extensive list of both known and novel HP1a-interacting proteins from Drosophila S2 cells and from whole organisms across embryonic, larval and adult stages....
ORGANISM(S): Drosophila melanogaster 
2014-07-03 | E-GEOD-56101 | biostudies-arrayexpress
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