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ProteomicsSILAC analysis of relative protein abundance in nuclei - AG3258 and AG11498
Premature aging disorders provide a lens through which to study the drivers of aging. In Hutchinson-Gilford progeria syndrome (HGPS) a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We used stable isotope labeling and quantitative mass spectromet...
ORGANISM(S): Homo sapiens (Human) 
2017-07-07 | PXD006012 | Pride
Human progeria silac 
ProteomicsSILAC analysis of relative protein abundance in nuclei - PRF168 and PRF167
Premature aging disorders provide a lens through which to study the drivers of aging. In Hutchinson-Gilford progeria syndrome (HGPS) a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We used stable isotope labeling and quantitative mass spectromet...
ORGANISM(S): Homo sapiens (Human) 
2017-07-07 | PXD006013 | Pride
Human progeria silac 
ProteomicsSILAC analysis of relative protein abundance in cytosol - AG3258 and AG11498
Premature aging disorders provide a lens through which to study the drivers of aging. In Hutchinson-Gilford progeria syndrome (HGPS) a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We used stable isotope labeling and quantitative mass spectromet...
ORGANISM(S): Homo sapiens (Human) 
2017-07-07 | PXD006014 | Pride
Human progeria silac 
ProteomicsSILAC pulse labeling in HGPS fibroblasts - WT samples
Premature aging disorders provide a lens through which to study the drivers of aging. In Hutchinson-Gilford progeria syndrome (HGPS) a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We used stable isotope labeling and quantitative mass spectromet...
ORGANISM(S): Homo sapiens (Human) 
2017-07-07 | PXD006015 | Pride
Human progeria silac wild type controls 
ProteomicsSILAC pulse labeling in HGPS fibroblasts - HGPS samples
Premature aging disorders provide a lens through which to study the drivers of aging. In Hutchinson-Gilford progeria syndrome (HGPS) a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We used stable isotope labeling and quantitative mass spectromet...
ORGANISM(S): Homo sapiens (Human) 
2017-07-07 | PXD006016 | Pride
Human progeria silac 
GenomicsGenome-wide maps of Nup98 binding in human embryonic stem cells, neural progenitors, neuron cells and lung fibroblasts
Recent evidence suggests that nucleoporins, well known components that control nucleo-cytoplasmic trafficking, have wide-ranging functions in developmental gene regulation that potentially extend beyond their role in nuclear transport. Whether the unexpected role of nuclear pore proteins in transcri...
ORGANISM(S): Homo sapiens 
2013-07-17 | E-GEOD-48996 | biostudies-arrayexpress
GenomicsNucleoporin Nup153 Regulates Stem Cell Pluripotency through Gene Silencing
Nucleoporins (Nups) are a family of proteins best known as the constituent building blocks of nuclear pore complexes (NPCs), the transport channels that mediate nuclear transport. Recent evidence suggest that several Nups have additional roles in controlling the activation and silencing of developme...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-64008 | biostudies-arrayexpress
ProteomicsIntegrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats
Aging is associated with the decline of protein, cell, and organ function. Here, we use an integrated approach to characterize gene expression, bulk translation, and cell biology in the brains and livers of young and old rats. We identify 468 differences in protein abundance between young and old an...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-10-05 | PXD002467 | Pride
Brain Rat Liver Aging 
ProteomicsR.norvegicus - Brain, SC (Orietal,cellsyst2015)
abundance based on Spectral counting, Interaction consistency score: 9.8, Coverage: 16
ORGANISM(S): 10116 
2015-00-00 | 860274101 | PAXDB
ProteomicsR.norvegicus - Liver, SC (Orietal,cellsyst2015)
abundance based on Spectral counting, Interaction consistency score: 14.6, Coverage: 14
ORGANISM(S): 10116 
2015-00-00 | 3089243329 | PAXDB
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