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GenomicsExpression data from human foreskin fibroblasts (HFFs) infected with Toxoplasma gondii
Expression data from human foreskin fibroblasts (HFFs) infected with Toxoplasma gondii
PRJNA962881 | ENA
TranscriptomicsExpression data from Human foreskin fibroblasts (HFFs) infected with Toxoplasma gondii.
Toxoplasma strains have been shown to modulate host cell transcription. We have found a type II Toxoplasma gene, GRA15, which activates the nuclear translocation of the NF-kappaB p65 transcription factor. We used microarrays to determine how GRA15II modulates host cell transcription. HFFs were infe...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-25468 | biostudies-arrayexpress
TranscriptomicsExpression data from human foreskin fibroblasts (HFFs) infected with type I strains of Toxoplasma gondii.
Type I strains of Toxoplasma gondii exhibit phenotypic variation, but it is uncertain how differently type I strains modulate the host cell. We determined differential host modulation by type I strains through microarray. HFFs were infected with RH-ERP, RH-JSR and GT1 for 24 hours. Total RNA was iso...
ORGANISM(S): Homo sapiens 
2013-08-20 | E-GEOD-44189 | biostudies-arrayexpress
TranscriptomicsExpression data from cyclohexamide treated Human Foreskin Fibroblasts (HFFs) infected with type I Toxoplasma gondii and stimulated with interferon gamma.
Pre-infection with Toxoplasma parasites inhibits induction of an interferon gamma responsive gene expression program. In this study we aimed to determine what role host negative regulatory proteins that are induced by Toxoplasma infection, such as SOCS-1, have in this inhibition. We used Affymetrix...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-34916 | biostudies-arrayexpress
TranscriptomicsSelective degradation of the miR-17 family members of the miR-17-92 cluster by human Cytomegalovirus
miRNA microarrays were used to investigate host miRNA expression profiles during HCMV clinical strain infection. Human foreskin fibroblasts (HFFs) were infected with the HCMV clinical strain Toledo. To mimic the attenuated strain, we used ToledoM-NM-^T15kb, which lacks the 15-kb genomic segment in t...
ORGANISM(S): Homo sapiens 
2013-05-09 | E-GEOD-43761 | biostudies-arrayexpress
TranscriptomicsExpression data from human foreskin fibroblasts (HFFs) infected with Toxoplasma gondii
Through targeted CRISPR screening of the Toxoplasma gondii secretome, we identified GRA57 as a novel secreted effector required for survival in interferon-gamma (IFNg)-activated human foreskin fibroblasts (HFFs). In this experiment we aimed to determine if GRA57 affects the host cell transcriptional...
ORGANISM(S): Homo sapiens 
2023-05-27 | GSE230866 | GEO
ProteomicsMass spectrometry based-proteomic analysis comparing the abundance of RNA-binding proteins (RBPs) between TE03 (I3) human embryonic stem cells (hESCs) and human foreskin fibroblasts (HFFs)
Here, we used high-resolution mass spectrometry to identify differentially expressed RNA-binding proteins (RBPs) between TE03 (I3) human embryonic stem cells (hESCs) and human foreskin fibroblasts (HFFs). 2102Ep embryonal carcinoma (EC) cells were used as a reference for pluripotent cells. This data...
ORGANISM(S): Homo sapiens (Human) 
2023-05-05 | PXD025284 | Pride
Shotgun proteomics Hescs Mass spectrometry Human foreskin fibroblasts Rbps Rna-binding proteins Human embryonic stem cells Hffs 
TranscriptomicsScreening of genes activated by phsiological E2F induced by gorwth stimulation
To identify genes activated by physiological E2F, we examined gene expression profiles using human normal fibroblasts (HFFs), which were starved of serum and re-stimulated with serum. To identify genes activated by growth stimulation, human normal fibroblasts (HFFs) were starved of serum for 48 hr, ...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-68081 | biostudies-arrayexpress
GenomicsEffect of Toxoplasma gondii efector TgIST on global transcriptome of human foreskin fibroblasts (HFFs) upon type I IFN activation
Effect of Toxoplasma gondii efector TgIST on global transcriptome of human foreskin fibroblasts (HFFs) upon type I IFN activation
PRJNA515062 | ENA
TranscriptomicsScreening of new target genes specifically activated by deregulated E2F
To identify genes specifically activated by deregulated E2F, we examined gene expression profiles using human normal fibroblasts (HFFs), which were starved of serum and re-stimulated with serum, over-expressed with E2F1 or expressed with adenovirus E1a to forcedly inactivate RB. To identify genes ac...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-67887 | biostudies-arrayexpress
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