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ProteomicsImplementation of microfluidics for antimicrobial susceptibility assays: issues and optimization requirements
Despite the continuous emergence of multi-drug resistant pathogens, the number of new antimicrobials reaching the market is critically low. Natural product peptides are a rich source of bioactive compounds, and advances in mass spectrometry have achieved unprecedented capabilities for the discovery ...
ORGANISM(S): Viola inconspicua 
2020-09-04 | PXD020857 | Pride
Microfluidics Antimicrobial susceptibility testing Viola 
ProteomicsMass spectrometric identification of antimicrobial peptides from medicinal seeds
Traditional medicinal plants contain a variety of bioactive natural products including cysteine-rich (Cys-rich) antimicrobial peptides (AMPs). Cys-rich AMPs are often crosslinked by multiple disulfide bonds which increase their resistance to chemical and enzymatic degradation. However, this class of...
ORGANISM(S): Sesamum indicum linum usitatissimum Trifolium pratense 
2022-02-16 | PXD029289 | Pride
Red clover Sesame Antimicrobial peptides Cysteine-rich peptides Linum usitatissimum Sesamum indicum Flax Trifolium pretense 
ProteomicsAmaranthus hypochondriacus seeds as a rich source of cysteine rich bioactive peptides
Amaranthus hypochondriacus is a highly nutritious alternative grain native to Central and South America but consumed worldwide. Increased interest in A. hypochondriacus has driven characterization of bioactive secondary metabolites and their impact on the human body. A. hypochondriacus seeds are kno...
ORGANISM(S): Amaranthus hypochondriacus 
2023-07-20 | PXD025965 | Pride
Peptidomics Proteomics Alternative grain Amaranthus hypochondriacus Mass spectrometry Cysteine rich peptides 
ProteomicsProteomic response of Escherichia coli to membrane lytic and iron chelating Amaranthus tricolor defensin
Plant defensins are a broadly distributed family of antimicrobial peptides which have been primarily studied for agriculturally relevant antifungal activity. Recent studies have probed defensins against gram negative bacteria revealing evidence for multiple mechanisms of action including membrane ly...
ORGANISM(S): Escherichia coli 
2021-04-14 | PXD024138 | Pride
Defensins Escherichia coli Amaranthus tricolor Iron chelation Iron reduction Membrane lysis 
ProteomicsExploring the diversity of cysteine-rich natural product peptides via MS/MS fingerprint ions
Stable and commonly bioactive cysteine-rich peptides (CRPs) have are typically discovered via mass shift analysis. However, the accurate assessment of unique CRP species in a given botanical species is often challenged by same mass species, post-translational modifications or modifications derived f...
ORGANISM(S): Lagenaria siceraria Viola <eudicots> 
2020-09-04 | PXD019501 | Pride
Lagenaria siceraria Cyclotides Viola communis Fingerprint ions Lc-ms/ms 
ProteomicsPolymyxin resistance in colibactin-producing Escherichia coli induces host genotoxicity
The complex reservoir of metabolite-producing bacteria in the gastrointestinal tract contributes tremendously to human health and disease. Bacterial composition, and by extension gut metabolomic composition, is undoubtably influenced by the use of modern antibiotics. Herein, we demonstrate that poly...
ORGANISM(S): Escherichia coli 
2021-07-15 | PXD025088 | Pride
Escherichia coli Colibactin Antimicrobial resistance 
ProteomicsReversible oxidative signaling in Chlamydomonas following nitrogen deprivation
As global temperatures climb to historic highs, the far-reaching effects of climate change have impacted agricultural nutrient availability. This has extended to low latitude oceans, where a deficit in both nitrogen and phosphorus stores has led to dramatic decreases in carbon sequestration in ocean...
ORGANISM(S): Chlamydomonas reinhardtii 
2020-06-28 | PXD019491 | Pride
Oxidation Ptm Lcms Signaling Chlamydomonas 
ProteomicsCrosslinking mass spectrometry unveils novel interactions and structural distinctions in the model green alga Chlamydomonas reinhardtii
Interactomics is an emerging field that seeks to identify both transient and complex-bound protein interactions that are essential for metabolic functions. Crosslinking mass spectrometry (XL-MS) has enabled untargeted global analysis of these protein networks, permitting largescale simultaneous anal...
ORGANISM(S): Chlamydomonas reinhardtii 
2021-11-03 | PXD026433 | Pride
Chlamydomonas Photosynthesis Crosslinking mass spectrometry Interactome Lc-ms/ms 
ProteomicsProfiling thimet oligopeptidase-mediated proteolysis in Arabidopsis thaliana
Plant stress caused by pathogens or though abiotic means (e.g. drought or temperature) reduces agricultural yields, causing substantial economic losses while reducing food security at the global level. It is critical to recognize how plants perceive stress signals to elicit responses for survival. E...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-01-25 | PXD019928 | Pride
Tops Arabidopsis Thimet oligopeptidases Peptidome 
ProteomicsMass spectrometry guided by transcriptomics reveals multiple classes of predicted antimicrobial peptides in Amaranthus tricolor
Traditional medicinal plants are rich reservoirs of antimicrobial agents, including antimicrobial peptides (AMPs). Herein, Amaranthus tricolor AMPs predicted in silico are identified via proteomics profiling. Bottom-up proteomics identified seven novel peptides spanning three AMP classes including l...
ORGANISM(S): Amaranthus tricolor 
2021-04-08 | PXD022242 | Pride
Peptidomics Mass spectrometry Amaranthus tricolor Antimicrobial peptides 
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