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MetabolomicsAn Airway Organoid-Based Screen Identifies a Role for the HIF1α-Glycolysis Axis in SARS-CoV-2 Infection
Not available
ORGANISM(S): Homo sapiens 
ST001921 | MetabolomicsWorkbench
TranscriptomicsTo identify genes responsive to treatment with the HIF2a inhibitor PT2399
HIF2a function is both necessary and sufficient for the growth of VHL-null clear cell Renal Cell Carcinoma (ccRCC). Targeting HIF2a function can therefore be a promising therapeutic strategy. We used microarray analysis to characterize a novel pharmacological inhibitor of HIF2a named PT2399. By comp...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-72959 | biostudies-arrayexpress
ProteomicsLineage factor-dependent signalling by kidney cancer-associated genetic alteration
As shown by large-scale human genetic data, cancer mutations display strong tissue-selectivity, but how this selectivity arises remains unclear. Here, using experimental models, functional genomics and analysis of patient samples, we demonstrate that the lineage transcription factor paired box 8 ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-14 | PXD029522 | Pride
Renal cell carcinoma Lineage factors Pax8 Hif2a 
TranscriptomicsHIF2A(EPAS1) Genome-Wide Localization in MRC5 Human Fibroblasts by Cut & Tag
HIF2A(EPAS1) geenome_wide localization by Cut & Tag in MRC5 human fibroblasts ectopically expressing HIF2A in the pBabe vector, and in control MRC5 human fibroblasts containing only the pBabe vector. 2 biological replicates were done for the MRC5-HIF2A cells. Cut & Tag with an anti-H3-K27me3 Ab was ...
ORGANISM(S): Homo sapiens 
2025-01-17 | E-MTAB-13732 | biostudies-arrayexpress
GenomicsHIF2A(EPAS1) Genome-Wide Localization in MRC5 Human Fibroblasts by Cut & Tag
HIF2A(EPAS1) Genome-Wide Localization in MRC5 Human Fibroblasts by Cut & Tag
PRJEB72033 | ENA
UnknownBMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury.
Not available
S-EPMC12095075 | biostudies-literature
UnknownTransient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration.
Not available
S-EPMC5983316 | biostudies-literature
TranscriptomicsTo identify genes responsive to treatment with the HIF2a inhibitor PT2399
HIF2a function is both necessary and sufficient for the growth of VHL-null clear cell Renal Cell Carcinoma (ccRCC). Targeting HIF2a function can therefore be a promising therapeutic strategy. We used microarray analysis to characterize a novel pharmacological inhibitor of HIF2a named PT2399. By comp...
ORGANISM(S): Homo sapiens 
2016-01-01 | GSE72959 | GEO
GenomicsThe BMAL1/HIF2A heterodimer modulates circadian variations of myocardial injury
The BMAL1/HIF2A heterodimer modulates circadian variations of myocardial injury
PRJNA1074411 | ENA
UnknownA novel EPAS1/HIF2A germline mutation in a congenital polycythemia with paraganglioma.
Not available
S-EPMC3570726 | biostudies-literature
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