Sort   by:  
 Page size 
GenomicsGenome wide profiling of PAX8 binding stes in PCCL3 rat cells
Analysis of PAX8 binding sites by chromatin immunoprecipitation coupled with ultra-high-throughput sequencing (ChIP-seq) in PCCL3 rat cells. Results provide insight into the contribution of this regulatory factor to transcription genome-wide. We generate a genome wide map of PAX8 binding sites in PC...
ORGANISM(S): Rattus norvegicus 
2012-06-27 | E-GEOD-26871 | biostudies-arrayexpress
ProteomicsBioID of PAX8 in human ovarian cancer cells
Investigation of interactors for the human transcription factor PAX8 using BioID-based proximity labeling, as described in Galli et al.
ORGANISM(S): Homo sapiens (Human) 
2021-03-09 | PXD021709 | Pride
Bioid Prdm3 Ovarian cancer Pax8 
ProteomicsLineage factor-dependent signalling by kidney cancer-associated genetic alteration
As shown by large-scale human genetic data, cancer mutations display strong tissue-selectivity, but how this selectivity arises remains unclear. Here, using experimental models, functional genomics and analysis of patient samples, we demonstrate that the lineage transcription factor paired box 8 ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-14 | PXD029522 | Pride
Renal cell carcinoma Lineage factors Pax8 Hif2a 
ProteomicsIn vitro crosslinking of PAX8 and PRDM3
MS crosslinking of PAX8 and PRDM3 using standard DSSO-based crosslinking
ORGANISM(S): Homo sapiens (Human) 
2021-03-09 | PXD021708 | Pride
Prdm3 Xlinkx Crosslinking-ms Pax8 
GenomicsChIP-seq for PAX8 and histone modifications in Renal Cell Carcinoma cell lines.
In this experiment we analyzed the genome wide occupancy of PAX8 by ChIP-seq in four Renal Cell Carcinoma cell lines. Additionally we performed ChIP-seq also for histone modifications correlated with transcriptional activity (H3K27ac), enhancers (H3K4me1) and promoters (H3K4me3). Unrelated IgG was u...
ORGANISM(S): Homo sapiens 
2019-06-28 | E-MTAB-7812 | biostudies-arrayexpress
TranscriptomicsGene expression profile changes upon knock-down of Pax8
In order to define the transcriptional network functionally regulated by Pax8 as well as infer its direct targets, we performed RNAi to knock-down Pax8 gene in FRTL-5 thyroid cells. Expression data from three independent silencing experiments were analyzed by microarray technology unraveling 2815 ge...
ORGANISM(S): Rattus norvegicus 
2011-12-20 | E-GEOD-29341 | biostudies-arrayexpress
GenomicsEpigenomic remodeling of the PAX8 cistrome in high grade serous ovarian cancer [ChIP-Seq]
We report mapping of the PAX8 cistrome in three high grade serous ovarian cancer cell lines (KURAMOCHI, OVSAHO, and JHOS4) compared to three benign immortalized fallopian tube cell lines (FT33, FT194, and FT246). We identified a highly conserved PAX8 binding pattern common across benign fallopian tu...
ORGANISM(S): Homo sapiens 
2016-08-08 | E-GEOD-79893 | biostudies-arrayexpress
GenomicsEffects of PAX8 rescue following PAX8 loss on gene expression in proximal tubule epithelial cells.
Effects of PAX8 rescue following PAX8 loss on gene expression in proximal tubule epithelial cells.
PRJNA1405763 | ENA
TranscriptomicsThe miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells During Carcinogenesis.
To comprehensively characterize microRNAs (miRNA) expression and their target genes in thyroid cancer, we performed next-generation sequencing expression analysis of this disease. Recent studies have found that only the most abundant microRNAs mediate significant target suppression. We sequenced sma...
ORGANISM(S): Homo sapiens 
2015-08-24 | E-GEOD-63511 | biostudies-arrayexpress
TranscriptomicsEpigenomic remodeling of the PAX8 cistrome in high grade serous ovarian cancer [RNA-Seq]
We report mapping of the PAX8 cistrome in three high grade serous ovarian cancer cell lines (KURAMOCHI, OVSAHO, and JHOS4) compared to three benign immortalized fallopian tube cell lines (FT33, FT194, and FT246). We identified a highly conserved PAX8 binding pattern common across benign fallopian tu...
ORGANISM(S): Homo sapiens 
2016-08-08 | E-GEOD-83100 | biostudies-arrayexpress
Sort   by:  
 Page size