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UnknownProlonged administration of azacitidine with or without entinostat for myelodysplastic syndrome and acute myeloid leukemia with myelodysplasia-related changes: results of the US Leukemia Intergroup trial E1905.
Not available
S-EPMC3986386 | biostudies-literature
TranscriptomicspiRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans
Transgenerational effects likely have wide-ranging implications for human health, biological adaptation and evolution, however their mechanism and biology remain poorly understood. Here we demonstrate that a germline nuclear small RNA/chromatin pathway can maintain epi-allelic inheritance for many g...
ORGANISM(S): Caenorhabditis elegans 
2012-06-25 | E-GEOD-38813 | biostudies-arrayexpress
TranscriptomicsRheumatoid arthritis and anti-TNF treatment
In 15 patients with rheumatoid arthritis the baseline expression (t=0) of type I IFN-regulated genes was determined in peripheral blood cells (PAXgene) using cDNA-microarrays and compared to levels one month after (t=1) anti-TNF treatment (infliximab). Therefore, we used 43K cDNA microarrays from th...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-19821 | biostudies-arrayexpress
TranscriptomicsLinkage of genomic biomarkers to whole organism endpoints in a Toxicity Identification Evaluation (TIE)
Aquatic organisms are exposed to many toxic chemicals and interpreting the cause and effect relationships between occurrence and impairment is difficult. Toxicity Identification Evaluation (TIE) provides a systematic approach for identifying responsible toxicants. TIE relies on relatively uninforma...
ORGANISM(S): Ampelisca abdita 
2012-12-21 | E-GEOD-41463 | biostudies-arrayexpress
ProteomicsMultimodal measurement of the transcriptome and proteome in G2/M arrested single cells using nanoSPLITS
Single-cell proteomic data from RO-3306 treated alveolar type II epithelial cells (C10) and untreated C10 cells. Cells were sorted using cellenONE onto several nanoSPLITS chips. Cell lysates were then split for parallel RNAseq and proteomic analysis. For proteomics recovery experiment where both chi...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-12-02 | MSV000090828 | MassIVE
ProteomicsMultimodal measurement of the transcriptome and proteome from dissociated human pancreatic islet cells using nanoSPLITS
Human pancreatic islets from two human donors (Prodo Laboratories) were acquired and cultured for 24 hr in pancreatic islet media (PIMS, Prodo Laboratories). Single cells were dissociated with TrypLE for ~15-30 minutes, washed with PBS, stained with Calcein-AM/propidium iodide, and sorted onto nanoS...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-07 | MSV000093330 | MassIVE
TranscriptomicsComparative genomic hybridization of Clostridium sporogenes and Clostridium botulinum strains
Clostridium botulinum is a heterogeneous Gram-positive species that comprises four genetically and physiologically distinct groups of bacteria that share the ability to produce botulinum neurotoxin, the most poisonous toxin known to man, and the causative agent of botulism, a severe disease of human...
ORGANISM(S): Clostridium botulinum 
2007-05-23 | E-TABM-264 | biostudies-arrayexpress
UnknownAre myocardial infarction--associated single-nucleotide polymorphisms associated with ischemic stroke?
Not available
S-EPMC3622211 | biostudies-literature
UnknownEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Not available
S-EPMC7787219 | biostudies-literature
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