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MetabolomicsL-fucose and fucoidan alleviate high-salt diet-promoted acute inflammation

Excessive salt intake is a widespread health issue observed in almost every country around the world. A high salt diet (HSD) has a strong correlation with numerous diseases, including hypertension, chronic kidney disease and autoimmune disorders. However, the mechanisms underlying HSD-promotion o...

2024-02-21 | MTBLS9134 | MetaboLights
MetabolomicsHigh Salt Diet versus Low Salt Diet in rats
Not available
ORGANISM(S): Rattus norvegicus 
ST001051 | MetabolomicsWorkbench
MetabolomicsSupplementation of Bacillus sp. DU-106 reduces hypercholesterolemia and ameliorates gut dysbiosis in high-fat diet rats

Gut microbiota modulation by a probiotic is a novel therapy for hypercholesterolemia mitigation. This study initially investigated the potential hypocholesterolemic effect of Bacillus sp. DU-106 in hypercholesterolemic rats and explored its potential relation with gut microbiota. Sprague-Dawley r...

2021-04-08 | MTBLS1168 | MetaboLights
MetabolomicsSacha inchi oil alleviates gut microbiota dysbiosis and improves hepatic lipid dysmetabolism in high-fat diet-fed rats
Dietary ω-3 polyunsaturated fatty acids (PUFAs) are beneficial for humans against the development of hyperlipidaemia, but the underlying mechanisms are still poorly understood. Here, we demonstrated that oral consumption of sacha inchi oil, which is rich in α-linolenic acid, alleviated dyslipidemia,...
2022-02-21 | MTBLS1225 | MetaboLights
MetabolomicsLactobacillus plantarum MR1 alleviates high-carbohydrate diet-induced oxidative stress and liver lipid deposition via upregulating uridine synthesis
The overconsumption of carbohydrates induces oxidative stress and lipid accumulation in the liver, which can be alleviated by modulation of intestinal microbiota; however, the underlying mechanism remains unclear. Here, we demonstrated that a strain affiliated with Lactobacillus plantarum (de...
2024-01-16 | MTBLS4262 | MetaboLights
MetabolomicsMulti-omics reveals taurine-mediated rumen microbial remodeling mitigates high-starch-diet-induced systemic inflammation and oxidative stress in fattening cattle

Background: With the pursuit of rapid intramuscular fat deposition in beef cattle, basal diets have increasingly shifted toward grain-based, energy-dense formulations. However, high-starch dietary regimens may induce host metabolic dysregulation, which is closely linked to both ruminal microbial ...

2025-09-25 | MTBLS13041 | MetaboLights
MetabolomicsAlleviation of high-fat diet-induced lipid metabolism disorders: Role of quinoa peptides in inhibiting high-activity BSH-producing gut microbiota and modulating of BA-FXR/TGR5 signaling
Abstract Background: Lipid metabolism disorders contribute significantly to various metabolic diseases and are closely related to gut microbiota dysbiosis. Our previous study showed that oral gavage of quinoa peptides (QPep) restored gut microbiota composition and alleviated liver lipid metabolism d...
2025-06-16 | MTBLS12584 | MetaboLights
ProteomicsHigh-salt diet promotes hypertrophic scarring through TRPC3-mediated mitochondrial Ca2+ homeostasis dysfunction
Diet High in salt content have been associated with cardiovascular disease and chronic inflammation. We recently demonstrated that transient receptor potential canonical 3 (TRPC3) channels regulate myofibroblast transdifferentiation in hypertrophic scars. Here, we examined how high salt activation o...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD042087 | Pride
High salt hypertrophic scar trpc3 
TranscriptomicsHigh salt primes a specific activation state of macrophages, M(Na)
Purpose: Investigate effects of high salt on human macrophage activation Methods: Human monocytes-derived macrophages were treated by additional 51mM NaCl for 24 hours (NaCl groups) or not (Control groups). mRNA profiles were generated by RNA-Seq, in triplicate, using Ion proton（Life tech). qRT–PCR ...
ORGANISM(S): Homo sapiens 
2015-09-23 | E-GEOD-68482 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of Sprague Dawley Rat Skin Treated with Aldosterone or Vehicle on High-Salt Diet for 2 or 14 Days
This study investigates the molecular mechanisms underlying salt-sensitive hypertension in a model of primary aldosteronism using RNA-Seq analysis of Sprague Dawley rat skin. Unilaterally nephrectomized rats were treated with aldosterone or vehicle and fed a high-salt or low-salt diet. Tissue electr...
ORGANISM(S): Rattus norvegicus 
2026-01-20 | E-MTAB-14749 | biostudies-arrayexpress
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