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ProteomicsDevelopment of A Image-based High-content Screening Assay Based on Clickable Probes for Identification of XPB Inhibitors
High-content screening (HCS) has become a powerful tool in drug discovery; however, their reliance on indirect readouts and surrogate markers limits their ability to directly assess drug-protein interactions at endogenous levels, particularly in subcellular contexts. Here, we report the development ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD059271 | Pride
High-content screening Click chemistry Xpb 
TranscriptomicsIncreased Persistence of gamma-H2AX as a Novel Approach to High Content Screening for Small Molecule Radiosensitizers
This study is about high content screening small molecule compound as radiosensitizer. Two compounds were got finally from a chemical bank. Our data indicate cancer cell lines became more sensitive to radiation after treatment with both two compounds respectively. In order to know the mechanism, mic...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-MTAB-845 | biostudies-arrayexpress
TranscriptomicsHigh content imaging in the screening of biomaterial-induced MSC behavior
Upon contact with a biomaterial, cells and surrounding tissues respond in a manner dictated by the physicochemical and mechanical properties of the material. Traditionally, cellular responses are monitored using invasive analytical methods that report the expression of genes or proteins. These analy...
ORGANISM(S): Homo sapiens 
2018-11-10 | E-MTAB-7352 | biostudies-arrayexpress
GenomicsHigh-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer
High-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer
PRJNA660398 | ENA
GenomicsIntegrated time-series analysis and high-content CRISPR screening delineate the dynamics of macrophage immune regulation
Integrated time-series analysis and high-content CRISPR screening delineate the dynamics of macrophage immune regulation
PRJNA1099184 | ENA
GenomicsScreening and transcriptomic analysis of high growth and lipid-content mutants of Crypthecodinium cohnii using acetyl-CoA carboxylase inhibitor sethoxydim
Screening and transcriptomic analysis of high growth and lipid-content mutants of Crypthecodinium cohnii using acetyl-CoA carboxylase inhibitor sethoxydim
PRJNA376212 | ENA
ProteomicsHigh-Content Screening Identifies A Small Molecule That Restores AP-4-dependent Protein Trafficking In Neuronal Models Of AP-4-Associated Hereditary Spastic Paraplegia
Unbiased phenotypic screens in patient-relevant disease models offer the potential to detect therapeutic targets for rare diseases. In this study, we developed a high-throughput screening assay to identify molecules that correct aberrant protein trafficking in adaptor protein complex 4 (AP-4) defici...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042950 | Pride
Human Autophagy Ipsc Drug screen Protein trafficking Hsp 
GenomicsIntegrated time-series analysis and high-content CRISPR screening delineate the dynamics of macrophage immune regulation [RNA-seq]
Integrated time-series analysis and high-content CRISPR screening delineate the dynamics of macrophage immune regulation [RNA-seq]
PRJNA1099192 | ENA
GenomicsIntegrated time-series analysis and high-content CRISPR screening delineate the dynamics of macrophage immune regulation [ATAC-seq]
Integrated time-series analysis and high-content CRISPR screening delineate the dynamics of macrophage immune regulation [ATAC-seq]
PRJNA1099193 | ENA
GenomicsHomo sapiens strain:THP1 cells
Pooled CRISPR Screening of High-content Cellular Phenotypes by Ghost Cytometry
PRJDB17362 | ENA
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