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ProteomicsMapping specificity, entropy, allosteric changes and substrates in blood coagulation proteases by a high-throughput protease screen
Proteases are crucial physiologic regulators of protein structure and function. While proteomic methods contributed extensively to protease characterization efforts, technical challenges remain in terms of throughput, scalability and large datasets of protease cleavages remain scarce. Here, we descr...
ORGANISM(S): Homo sapiens (Human) 
2021-02-05 | PXD018976 | Pride
High-throughput protease screen Substrates Blood coagulation proteases Specificity Entropy Allostery 
ProteomicsTarget quantification of octapeptide for Thrombin and FX
Proteases are crucial physiologic regulators of protein structure and function. While proteomic methods contributed extensively to protease characterization efforts, technical challenges remain in terms of throughput, scalability and large datasets of protease cleavages remain scarce. Here, we descr...
ORGANISM(S): Homo sapiens (Human) 
2021-02-04 | PXD020320 | Pride
High-throughput protease screen Substrates Blood coagulation proteases Specificity Entropy Allostery 
UnknownTherapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Not available
S-EPMC7733812 | biostudies-literature
UnknownOMA1 High-Throughput Screen Reveals Protease Activation by Kinase Inhibitors.
Not available
S-EPMC8604787 | biostudies-literature
TranscriptomicsGene expression profiling of genes differentially expressed by oral carcinoma Ca9-22 and SLPI-deficient Ca9-22 (ΔSLPI) cells
We used the myoma model in conjunction with gene expression profiling with microarray data as an efficient tool for high throughput analysis and to screen for differentially expressed genes. Our aim was to identify candidates playing an important role in SLPI and/or MMP-promoted tumor invasion by co...
ORGANISM(S): Homo sapiens 
2016-08-22 | E-GEOD-78501 | biostudies-arrayexpress
UnknownIdentification and biochemical characterization of small-molecule inhibitors of west nile virus serine protease by a high-throughput screen.
Not available
S-EPMC2533463 | biostudies-literature
UnknownAn activation-based high throughput screen identifies caspase-10 inhibitors.
Not available
S-EPMC11854450 | biostudies-literature
ProteomicsQuantitative analysis of design substrates
Proteases are crucial physiologic regulators of protein structure and function. While proteomic methods contributed extensively to protease characterization efforts, technical challenges remain in terms of throughput, scalability and large datasets of protease cleavages remain scarce. Here, we descr...
ORGANISM(S): Homo sapiens (Human) 
2021-02-04 | PXD020321 | Pride
High-throughput protease screen Substrates Blood coagulation proteases Specificity Entropy Allostery 
ProteomicsTargeted quantification of octapeptide substrate of FII and FX
Proteases are crucial physiologic regulators of protein structure and function. While proteomic methods contributed extensively to protease characterization efforts, technical challenges remain in terms of throughput, scalability and large datasets of protease cleavages remain scarce. Here, we descr...
ORGANISM(S): Homo sapiens (Human) 
2021-02-04 | PXD020319 | Pride
High-throughput protease screen Substrates Blood coagulation proteases Specificity Entropy Allostery 
UnknownHigh-throughput screening for the identification of small-molecule inhibitors of the flaviviral protease.
Not available
S-EPMC5065773 | biostudies-literature
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