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ProteomicsMapping specificity, entropy, allosteric changes and substrates in blood coagulation proteases by a high-throughput protease screen
Proteases are crucial physiologic regulators of protein structure and function. While proteomic methods contributed extensively to protease characterization efforts, technical challenges remain in terms of throughput, scalability and large datasets of protease cleavages remain scarce. Here, we descr...
ORGANISM(S): Homo sapiens (Human) 
2021-02-05 | PXD018976 | Pride
High-throughput protease screen Substrates Blood coagulation proteases Specificity Entropy Allostery 
TranscriptomicsHigh throughput screening for chemical inducers of stumpy formation in Trypanosoma brucei
During the bloodstream stage of the Trypanosoma brucei lifecycle, the parasite exists as the proliferative slender-form or the non-proliferative, transmissible, stumpy-form. The transition from the slender to stumpy-form is stimulated by a density-dependent mechanism and is important in infection dy...
ORGANISM(S): Trypanosoma brucei brucei 
2014-01-21 | E-GEOD-46483 | biostudies-arrayexpress
GenomicsClonal expansion analysis of transposon insertions by high-throughput sequencing identifies candidate cancer genes in a PiggyBac mutagenesis screen
Somatic transposon mutagenesis in mice is an efficient strategy to investigate the genetic mechanisms of tumorigenesis. The identification of tumor driving transposon insertions traditionally requires the generation of large tumor cohorts to obtain information about common insertion sites. Tumor dri...
ORGANISM(S): Mus musculus 
2013-08-28 | E-GEOD-46210 | biostudies-arrayexpress
ModelsRahman2022 - High throughput antibacterial screening with machine learning.
Prediction of antimicrobial potential using a dataset of 29537 compounds screened against the antibiotic resistant pathogen Burkholderia cenocepacia. The model uses the Chemprop Direct Message Passing Neural Network (D-MPNN) and has an AUC score of 0.823 for the test set. It has been used to virtual...
2024-04-22 | MODEL2404080002 | BioModels
Machine Learning Model Ersilia 
GenomicsHigh throughput CRISPRi screen identifies viability lncRNAs in human monocytes
High throughput CRISPRi screen identifies viability lncRNAs in human monocytes
PRJNA1167345 | ENA
GenomicsHigh-throughput screen identifies metabolite regulators of endothelial function
High-throughput screen identifies metabolite regulators of endothelial function
PRJNA1469023 | ENA
GenomicsHigh-throughput Oligopaint screen identifies druggable 3D genome regulators
High-throughput Oligopaint screen identifies druggable 3D genome regulators
PRJNA820829 | ENA
UnknownHigh-throughput fluorescence anisotropy screen for inhibitors of the oncogenic mRNA binding protein, IMP-1.
Not available
S-EPMC4072326 | biostudies-literature
GenomicsHigh throughput CRISPRi screen identifies viability lncRNAs in human monocytes [II]
High throughput CRISPRi screen identifies viability lncRNAs in human monocytes [II]
PRJNA1167346 | ENA
TranscriptomicsPhenothiazine Neuroleptics Signal To The Human Insulin Promoter As Revealed By A Novel Human b-Cell Line Based Screen
(original Title) Phenothiazine Neuroleptics Signal To The Human Insulin Promoter As Revealed By A Novel Human b-Cell Line Based High-Throughput Screen. To address the current deficiency in human beta-cell models, we have developed a cell line from human islets in which the expression of insulin and...
ORGANISM(S): Homo sapiens 
2010-08-06 | E-GEOD-18821 | biostudies-arrayexpress
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