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ProteomicsUbiquitinated proteome of E15.5 murine cortical neurons
TRIM9 and TRIM67 are neuronally-enriched E3 ubiquitin ligases essential for neuronal morphogenesis and responses to the axon guidance cue netrin-1. Deletion of either gene in the mouse results in subtle neuroanatomical anomalies yet overt deficits in spatial learning and memory. The identify of few ...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD021818 | Pride
Embryonic cortical neurons Ubiquitinate proteome Orbitrap fusion lumos 
ProteomicsTRIM9 and TRIM67 interactome using the BioID approach
TRIM9 and TRIM67 are two brain enriched E3 uiquitin ligases that are critical to neuronal form and function both during embryonic development and in adult-born neurons. TRIM9 and TRIM67 interact with cytoskeletal and exocytic proteins, but the full interactome is not known.Using the BioID approach w...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD021758 | Pride
Embryonic cortical neurons Orbitrap fusion lumos 
ProteomicsUbiquitination of the actin polymerase VASP
Filopodia are dynamic, actin-rich structures that extend outward from the cell to explore and respond to cues in the local environment. The actin polymerase VASP is a component of the filopodial tip complex, where it regulates actin polymerization and filopodial dynamics. Previously, we showed that ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-17 | PXD041196 | Pride
Actin  ubiquitin  vasp  post-translational modification 
ProteomicsA phase separation mechanism underlies development of cancer and aberrant organization of three-dimensional chromatin structure
Development of cancer is intimately associated with genetic abnormalities that target proteins with intrinsically disordered regions (IDRs). In human hematological malignancies, recurrent chromosomal translocation of nucleoporin (NUP98 or NUP214) generates an aberrant chimera that invariably retains...
ORGANISM(S): Homo sapiens (Human) 
2021-04-22 | PXD023548 | Pride
Oncogenesis Homeodomain-containing transcription factor Intrinsically disordered regions (idrs) Bioid 
UnknownThe anchoring method: Estimation of interviewer effects in the absence of interpenetrated sample assignment.
Not available
S-EPMC9983757 | biostudies-literature
UnknownPathologic findings at risk-reducing salpingo-oophorectomy: primary results from Gynecologic Oncology Group Trial GOG-0199.
Not available
S-EPMC4178524 | biostudies-literature
ProteomicsZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
Recurring chromosomal translocation t(10;17)(p15;q21) present in a subset of human acute myeloid leukemia (AML) patients creates an aberrant fusion gene termed ZMYND11-MBTD1 (ZM); however, its function remains undetermined. Here, we show that ZM confers primary murine hematopoietic stem/progenitor c...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-21 | PXD023702 | Pride
Acute myeloid leukemia H3k36me3 Bromodomain 
TranscriptomicsDrought stressed corn grown on summit/shoulder vs. well hydrated corn grown on backslope
This study was designed to identify changes in gene expression that occur when corn was grown on different landscape features. Specifically on the backslope or summit/shoulder of a hill. In rolling landscapes, plant available water varies drastically by location and soil type. Almost simultaneously...
ORGANISM(S): Zea mays 
2011-11-05 | E-GEOD-33494 | biostudies-arrayexpress
TranscriptomicsHuman bronchial epithelial cells_Passage 3 vs. passage 0
Squamous metaplasia is common in smokers and is associated with airway obstruction in chronic obstructive pulmonary disease (COPD). A major mechanism of airway obstruction in COPD is thickening of the small airway walls. We asked whether squamous metaplasia actively contributes to airway wall thicke...
ORGANISM(S): Homo sapiens 
2007-08-30 | E-GEOD-7557 | biostudies-arrayexpress
UnknownMolecular, Metabolic, and Subcellular Mapping of the Tumor Immune Microenvironment via 3D Targeted and Non-Targeted Multiplex Multi-Omics Analyses.
Not available
S-EPMC10930466 | biostudies-literature
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