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ProteomicsHuman cerebrospinal fluid proteoform profiling
. In this study, we have investigated the capacities of last-generation Ultra-High Resolution Q-Tof systems to deal with high complexity intact protein samples, have developed the tools to process the intact protein data in an existing label-free quantification pipeline, and have evaluated the appro...
ORGANISM(S): Homo sapiens (Human) 
2018-04-05 | PXD005314 | Pride
Proteoforms Alzheimer Csf 
ProteomicsDeciphering Black Extrinsic Tooth Stains composition in Children using metaproteomics
The present study focuses on the use of a metaproteomic approach to analyse Black Extrinsic Tooth Stains, a specific type of pigmented extrinsic substance, in a cohort of 96 Children. Metaproteomics is a powerful emerging technology that successfully enabled human protein and bacterial identificatio...
ORGANISM(S): Homo sapiens (Human) 
2024-07-25 | PXD029245 | Pride
Saliva Dental plaque Oral pathology Metaproteomics 
ProteomicsTemporal analysis of tear fluid proteome reveals critical corneal repair events after photorefractive surgery
The cornea is the transparent tissue at the forefront of the eye. Its outermost layer, the corneal epithelium, acts as a protective barrier for the ocular chamber. The cornea is avascular and its homeostasis relies on alternative sources to receive nutrients and growth factors, essential for maintai...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-10 | PXD067691 | Pride
Tear film Epithelium Wound healing Proteomic Cornea 
ProteomicsComparative analysis of tear proteomics in PAX6 mutant and control mice of both sexes before and after abrasion
Our team is working on aniridia, an autosomal dominant condition and has used a mouse model. The cornea, the eye’s first avascular and transparent optical surface, is covered by a stratified epithelium that constantly renews itself; any disruption compromises transparency and threatens vision. The t...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-01 | PXD070553 | Pride
Tear proteomics Wound healing Pax6 Aniridia 
ProteomicsPLAPAX6: Proteomic study of tears from patients with a PAX6 mutation
The cornea is the eye’s first optical surface, avascular and transparent, covered externally by a stratified epithelium that constantly renews itself. Disruption in this renewal compromises transparency, potentially leading to vision loss. The corneal surface is protected and nourished by the tear f...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD066455 | Pride
Pax6 Aniridia Tears proteomic 
UnknownNatural history, dynamics, and ecology of human papillomaviruses in genital infections of young women: protocol of the PAPCLEAR cohort study.
Not available
S-EPMC6576111 | biostudies-literature
ProteomicsStable Isotope Labeling by Amino acid in Vivo (SILAV)
Intravenous administration of stable isotope labeled amino acid ((13)C6-leucine) to humans recently made it possible to study the metabolism of specific biomarkers in plasma using High Resolution mass spectrometry (MS). This labeling approach could be of great interest for monitoring many leucine-co...
ORGANISM(S): Homo Sapiens 
2025-11-10 | PXD046373 | panorama
ProteomicsStable Isotope Labeling by Amino acid in Vivo (SILAV)
Intravenous administration of stable isotope labeled amino acid ((13)C6-leucine) to humans recently made it possible to study the metabolism of specific biomarkers in cerebrospinal fluid (CSF) and in plasma using targeted mass spectrometry (MS). This labeling approach could be of great interest for ...
ORGANISM(S): Homo Sapiens 
2025-11-15 | PXD046142 | panorama
ProteomicsModeling the simultaneous dynamics of proteins in blood plasma and the cerebrospinal fluid in human in vivo
The analysis of protein dynamics or turnover in patients has the potential to reveal altered protein recycling such as in Alzheimer disease, and to provide informative data regarding drug efficacy, or certain biological processes. The observed protein dynamics in a solid tissue or a fluid is the net...
ORGANISM(S): Homo Sapiens 
2025-04-30 | PXD047851 | panorama
ProteomicsTau Profiling of Brain Extracellular Vesicles Reveals PHF6 Peptide as Core for Pathological Tau Seeding in Alzheimer's Disease
EVs are bilipid spheres known for their role in cellular communication through transport of proteins, lipids, RNA and more. In the brain, EVs are directly released in the interstitial fluid surrounding neural cells and hence entitled brain-derived EVs (BD-EVs). Human BD-EVs of AD patients contain se...
ORGANISM(S): Homo Sapiens 
2026-09-06 | PXD067593 | panorama
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