Histone demethylase

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Unknown (1833)
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Mus musculus (590)
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Organisms

Mus musculus (411)
Homo sapiens (380)
Arabidopsis thaliana (59)
Drosophila melanogaster (20)
Caenorhabditis elegans (20)
Saccharomyces cerevisiae (13)
Solanum lycopersicum (9)
Rattus norvegicus (8)
Glycine max (7)
Schizosaccharomyces pombe (6)
Gallus gallus (5)
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Aspergillus nidulans (4)
Xenopus tropicalis (4)
Sus scrofa (4)
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Tetrahymena thermophila (2)
Saccharomyces cerevisiae S288C (2)
Mus musculus musculus (2)
Oryza sativa (2)
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Rattus norvegicus albus (1)
Eublepharis macularius (1)
Thlaspi arvense (1)
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Chlorocebus sabaeus (1)
Mus (1)
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Technology Type

Mass Spectrometry (53)
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Data-independent acquisition (2)
Gel-based experiment (2)
SWATH MS (2)
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Mass spectrometry assay (1)
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Instrument Platform

Illumina NovaSeq 6000 (21)
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Illumina HiSeq 2000 (2)
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Publication Date

2016 (124)
2024 (118)
2026 (110)
2023 (108)
2025 (103)
2022 (102)
2015 (102)
2014 (101)
2013 (92)
2021 (83)
2012 (80)
2020 (74)
2019 (74)
2018 (72)
2010 (59)
2017 (49)
2011 (45)
2009 (11)
2008 (5)
2007 (5)

CHEBI ID

CHEBI:14434 (1)
CHEBI:166843 (1)
CHEBI:46229 (1)
CHEBI:69426 (1)
CHEBI:89582 (1)
CHEBI:17319 (1)
CHEBI:20794 (1)
CHEBI:16231 (1)
CHEBI:68443 (1)
CHEBI:28393 (1)
CHEBI:21563 (1)
CHEBI:70989 (1)
CHEBI:41321 (1)
CHEBI:33283 (1)
CHEBI:88824 (1)
CHEBI:28997 (1)
CHEBI:17768 (1)
CHEBI:75145 (1)
CHEBI:16192 (1)
CHEBI:16497 (1)
CHEBI:82965 (1)
CHEBI:16709 (1)
CHEBI:17202 (1)
CHEBI:184023 (1)
CHEBI:18261 (1)
CHEBI:30837 (1)
CHEBI:16708 (1)
CHEBI:506227 (1)
CHEBI:73685 (1)
CHEBI:17752 (1)

Metabolite Name

Adenosine (2)
Deoxyadenosine monophosphate (dAMP) (1)
Deoxycytidine monophosphate (dCMP) (1)
Uridine diphosphate glucose (UDP-D-Glucose) (1)
NG,NG-Dimethyl-L-arginine (ADMA) (1)
Dihydroxy-acetone-phosphate (1)
Thiamine monophosphate (TMP) (1)
FA 18:4+1O (1)
Gamma-Glutamyl-L-methionine (1)
Gamma-L-Glutamyl-L-phenylalanine (1)
Gamma-L-Glutamyl-L-valine (1)
L-Methionine sulfoxide (1)
Adenosine 5'-diphosphate (1)
Beta-D-Glucosamine (1)
Cholesterol sulfate (1)
Inosine 5'-monophosphate (IMP) (1)
Imidazole (1)
N-ACETYL-DL-SERINE (1)
Allantoic acid (1)
7-methylguanosine (1)
Riboflavin (Vitamin B2) (1)
Ethanolamine (1)
Deoxyguanosine triphosphate (dGTP) (1)
Folic acid (1)
2'-Deoxyguanosine 5'-monophosphate (dGMP) (1)
Cytidine 5'-monophosphate (CMP) (1)
L-Carnosine (1)
L-Citrulline (1)
Ureidopropionic acid (1)
LysoPE(18:0/0:0) (1)

First Public Date

2024 (124)
2025 (119)
2022 (105)
2026 (104)
2014 (103)
2023 (98)
2021 (81)
2019 (74)
2020 (71)
2018 (64)
2016 (55)
2017 (50)
2015 (41)
2013 (38)

Classification

protozoa (6)
fungi (5)

Modification

N6 (2)
N6-dimethyl-L-lysine (1)

Study status

Not provided (1)

Study type

Transcription profiling by array (153)
ChIP-seq (118)
RNA-seq of coding RNA (81)
ChIP-chip by tiling array (21)
Transcription profiling by RT-PCR (14)
Methylation profiling by high throughput sequencing (7)
Other (6)
RNA-seq of coding RNA from single cells (6)
Methylation profiling by array (5)
Comparative genomic hybridization by array (3)
Unknown experiment type (2)
CLIP-Seq (2)
Cell line - High-throughput sequencing (2)
ATAC-seq (2)
MicroRNA profiling by array (2)
CUT&TAG (1)
Cell line - One-color microarray (1)
Human - One-color microarray (1)
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RNAi profiling by array (1)
ChIP-chip by array (1)
DNA-seq (1)
CUT&RUN (1)
RNA-seq of non coding RNA (1)
Interventional (1)

Release Date

2022 (179)
2021 (167)
2023 (166)
2015 (161)
2020 (160)
2016 (158)
2014 (144)
2018 (138)
2025 (135)
2024 (127)
2013 (125)
2019 (125)
2017 (121)
2012 (106)
2010 (86)
2011 (74)
2026 (32)
2008 (26)
2009 (19)
2007 (11)
2006 (2)
2005 (1)
1999 (1)

Lab affiliation

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, 75390, TX, USA (2)
1. Ministry of Education Key Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences, Zhejiang University, Hangzhou, China 2. Cancer Center, Zhejiang University, Hangzhou, China (1)
1Department of Biochemistry and Biophysics, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States (1)
Aarhus University Institute of Molecular Biology and Genetics Universitetsbyen 81 8000 Aarhus Denmark (1)
Babraham Institute Cambridge UK (1)
Biological Mass Spectrometry Lab, Department of Translational Medicine (DiMeT), Center for Translational Research on Autoimmune & Allergic Diseases - CAAD, University of Piemonte Orientale, Novara, Italy (1)
Centre for medicines discovery, University of Oxford (1)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA (1)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States (1)
Department of Biological Sciences, Vanderbilt University (1)
Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland (1)
Department of Biomedical Science E-04, Florey building Firth Court, Western Bank University of Sheffield Sheffield, S10 2TN United Kingdom (1)
Department of Biotechnology, TU Delft, NL (1)
Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan 20139, Italy (1)
Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy (1)
Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy (1)
Department of Microbiology and Molecular Genetics University of Pittsburgh (1)
Department of Molecular Genetics (190g), University of Hohenheim (1)
Department of Molecular Integrative Physiology University of Illinois at Urbana/Champaign Urbana, IL 61801 (1)
Department of Plant Biology, Carnegie Instition for Science (1)
Department of Structural and Molecular Biology IBMB-CSIC Barcelona, Spain (1)
Dr. Eric U. Selker Institute of Molecular Biology University of Oregon Eugene, Oregon 97403, USA (1)
European Institute of Oncology, Milan (1)
European Instutute of Oncology (1)
Feinberg Cardiovascular Research Institute, Northwestern University (1)
German cancer research center (DKFZ), Germany (1)
Harvard Medical School Department of Medical Oncology Dana-Farber Cancer Institute 450 Brookline Ave. SM1070 Boston, MA 02215 (1)
Insitute of Molecular Biology and Tumor Research (IMT) University Marburg, Germany (1)
Institute for Research in Biomedicine, Baldiri i Reixac 10, Barcelona 08028, Spain (1)
Kidney and Dialysis Institute of Shanghai (1)

Location

United Kingdom (1)

Keyword

Domatinostat (1)
Bavencio (1)

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Histone H3K4me3 Demethylase RBP2 Transcriptionally Activates PPARγ to Drive Lipid Metabolic Reprogramming in Gastric Carcinoma

This work investigates epigenetic driven lipid metabolic reprogramming in gastric carcinoma. We characterize that histone H3K4me3 demethylase RBP2 transcriptionally activates PPARgama by binding to its promoter region,thereby promoting lipogenic gene expression and intracellular lipid accumulatio...

2026-08-14 | MTBLS15324 | MetaboLights

Histone Demethylase Lsd1 is Required to Repress Hematopoietic Stem and Progenitor Cell Signatures During Blood Cell Maturation

Here we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on LysM-bM-^@M-^I4 or LysM-bM-^@M-^I9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis in primary hematopoietic cells, combining global occ...

ORGANISM(S): Mus musculus

2013-06-25 | E-GEOD-40440 | biostudies-arrayexpress

CpG islands recruit a histone H3 lysine 36 demethylase

This SuperSeries is composed of the following subset Series: GSE18588: CpG islands recruit a histone H3 lysine 36 demethylase [Illumina sequencing data] GSE21201: CpG islands recruit a histone H3 lysine 36 demethylase [Agilent data] Refer to individual Series

ORGANISM(S): Homo sapiens

2010-04-26 | E-GEOD-21202 | biostudies-arrayexpress

The S. cerevisiae histone demethylase Jhd1 fine-tunes the distribution of H3K36me2

Histone methylation plays important roles in the regulation of chromatin dynamics and transcription. Steady state levels of histone lysine methylation are regulated by a balance between enzymes that catalyze either the addition or removal of methyl groups. Using an activity-based biochemical approac...

ORGANISM(S): Saccharomyces cerevisiae

2010-06-11 | E-GEOD-7627 | biostudies-arrayexpress

CpG islands recruit a histone H3 lysine 36 demethylase [Illumina sequencing data]

Eukaryotic gene expression profiles are largely defined by transcription factors that recognize specific DNA sequences in gene regulatory regions and impact RNA polymerase recruitment and transcription. In addition to specific core promoter regulatory elements, up to 70% of genes in higher eukaryote...

ORGANISM(S): Mus musculus

2010-04-27 | E-GEOD-18588 | biostudies-arrayexpress

Phosphorylation of methyltransferase Set2p and demethylase Jhd1p and its association with histone H3K36 methylation and stress response pathways in Saccharomyces cerevisiae

Histone lysine methylation is a key epigenetic modification that regulates eukaryotic transcription. In Saccharomyces cerevisiae, it is controlled by a reduced but evolutionarily conserved suite of methyltransferase (Set1p, Set2p, Dot1p, and Set5p) and demethylase (Jhd1p, Jhd2p, Rph1p, and Gis1p) en...

ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast)

2022-03-07 | PXD029088 | Pride

Genome-wide map of lysine specific demethylase 1 (LSD1) in mouse embryonic stem cells.

We report the identification of LSD1 binding genomic regions in mouse embryonic stem cells (ESC) by high throughput sequencing. By obtaining over 10 million 36 bp reads of sequence from each chromatin immunoprecipitated DNA, we generated genome-wide maps for LSD1 and histone H3 dimethylated on lysin...

ORGANISM(S): Mus musculus

2012-10-03 | E-GEOD-18515 | biostudies-arrayexpress

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

This SuperSeries is composed of the following subset Series: GSE34672: Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [Illumina HumanHT-12 gene expression array] GSE34725: Inhibition of the LSD1 (KDM1A) demethylase...

ORGANISM(S): Homo sapiens

2012-03-14 | E-GEOD-34726 | biostudies-arrayexpress

Loss of histone demethylase JARID1C triggers genomic instability in cancer.

Chromatin remodelers are recurrently mutated in cancer. Among these, JARID1C, (KDM5C) a histone demethylase, is frequently inactivated in clear cell renal cell carcinoma (ccRCC) patients. How the genetic inactivation of JARID1C leads to cancer remains largely unknown. Here we report that JARID1C bin...

ORGANISM(S): Homo sapiens

2015-11-09 | E-GEOD-73267 | biostudies-arrayexpress

Glioblastoma initiating cells are sensitive to histone demethylase inhibition due to epigenetic deregulation

Tumor-initiating cells are a subpopulation of cells that have self-renewal capacity to regenerate a tumor. Here, we identify stem cell-like chromatin features in human glioblastoma initiating cells (GICs) and link them to a loss of the repressive histone H3 lysine 9 trimethylation (H3K9me3) mark. In...

EGAS00001003750 | EGA

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