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GenomicsThe histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation
Here we show that T-box proteins team up with chromatin modifying enzymes to drive the expression of the key lineage regulator, Eomes during endodermal differentiation of embryonic stem (ES) cells. The Eomes locus is maintained in a transcriptionally poised configuration in ES cells. During early di...
ORGANISM(S): Mus musculus 
2013-04-18 | E-GEOD-44764 | biostudies-arrayexpress
GenomicsCritical role of histone demethylase Jmjd3 in the regulation of CD4+ T cell differentiation
Epigenetic factors have been implicated in the regulation of CD4(+) T-cell differentiation. Jmjd3 plays a role in many biological processes, but its in vivo function in T-cell differentiation remains unknown. Here we report that Jmjd3 ablation promotes CD4(+) T-cell differentiation into Th2 and Th17...
ORGANISM(S): Mus musculus 
2015-06-13 | E-GEOD-58775 | biostudies-arrayexpress
ProteomicsHistone demethylase JMJD3 is a key epigenetic activator of FGF21 signaling-induced hepatic autophagy and lipolysis
Autophagy is essential for cellular survival and energy homeostasis under nutrient deprivation. Despite the emerging importance of nuclear events in autophagy regulation, epigenetic control of autophagy gene transcription remains unclear. Here, we identify Jumonji-D3 (JMJD3/KDM6B) histone demethylas...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD015672 | Pride
Fgf21 Autophagy Mouse Histone demethylase jmjd3 Lypolysis 
GenomicsGenome wide trimethyl-H3K27 distibution in macrophages from wild-type and Jmjd3-/- macrophages.
Jmjd3 is trimethyl H3K27 specific demethylase required for M2 macrophage polarization. Genomic fragments obtained from wild-type and Jmjd3-/- mouse macrophages were immunoprecipitated with anti H3K27me3 Ab, and deep sequencing was performed. wild-type and Jmjd3-/- macrophages
ORGANISM(S): Mus musculus 
2010-08-22 | E-GEOD-23297 | biostudies-arrayexpress
GenomicsGenome wide maps of histone demethylase jmjd3, chromatin state and RNA pol in mouse bone marrow-derived macrophages
Inflammatory responses triggered by either microbial or endogenous stimuli rely on a complex transcriptional program that involves the differential expression of hundreds of genes. Jmjd3, a JmjC family histone demethylase (HDM), is quickly induced by the transcription factor NF-kB in response to inf...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-17631 | biostudies-arrayexpress
GenomicsThe histone lysine demethylase JMJD3/KDM6B is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner
The JmjC domain containing protein JMJD3/KDM6B catalyses H3K27me3 and H3K27me2 demethylation. JMJD3 appears to be highly regulated at the transcriptional level and is upregulated in response to diverse stimuli such as differentiation inducers and stress signals. Accordingly, JMJD3 has been linked to...
ORGANISM(S): Homo sapiens 
2014-06-11 | E-GEOD-55912 | biostudies-arrayexpress
TranscriptomicsCharacterizing the contrasting roles of JMJD3 and UTX histone demethylases in T cell acute lymphoblastic leukemia [short_hairpins_RNA-seq]
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we abrogated the expression of JMJD3 (KDM6B) and UTX (KDM6A) H3K27me3 demethylases in human T-ALL lines and assayed for genome-wide expression ...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-56689 | biostudies-arrayexpress
GenomicsGenome wide binding sites of Smad3 and JMJD3 in neural stem cells
Neural development requires crosstalk between signaling pathways and chromatin. In this study, we demonstrate that neurogenesis is promoted by an interplay between the TGFM-NM-2 pathway and the H3K27me3 histone demethylase (HDM) JMJD3. Genome-wide analysis showed that JMJD3 is targeted to gene promo...
ORGANISM(S): Mus musculus 
2012-05-30 | E-GEOD-36673 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in mature OT-II TCR transgenic CD4 SP thymocytes, either Jmjd3- and Utx-deficient or -sufficient.
The biological functions of histone demethylases Jmjd3 and Utx remain poorly understood. We assessed such functions in developing T cells, using conditional (CD4-Cre-mediated) gene disruption, by inactivating Kdm6a and Kdm6b, respectively encoding Utx and Jmjd3, in immature CD4+CD8+ thymocytes. We c...
ORGANISM(S): Mus musculus 
2015-09-17 | E-GEOD-70363 | biostudies-arrayexpress
GenomicsCharacterizing the contrasting roles of JMJD3 and UTX histone demethylases in T cell acute lymphoblastic leukemia [JMJD3_CUTLL1_ChIP-seq]
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we assayed for genome-wide localization of JMJD3 enrichment. This piece of data was further integrated to expression changes using RNA sequenci...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-56694 | biostudies-arrayexpress
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