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MetabolomicsSex-dependent effects of FGF21 on hepatic metabolism
Not available
ORGANISM(S): Mus musculus 
ST002249 | MetabolomicsWorkbench
TranscriptomicsThe role of FGF21 in aging and aging-related diseases
Aging and aging-related diseases represent an increasing burden on modern society. Thus, drugs that retard the aging process are highly desirable. Fibroblast growth factor-21 (FGF21) is a hormone secreted by the liver during fasting that elicits diverse aspects of the adaptive starvation response....
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-39313 | biostudies-arrayexpress
ProteomicsHistone demethylase JMJD3 is a key epigenetic activator of FGF21 signaling-induced hepatic autophagy and lipolysis
Autophagy is essential for cellular survival and energy homeostasis under nutrient deprivation. Despite the emerging importance of nuclear events in autophagy regulation, epigenetic control of autophagy gene transcription remains unclear. Here, we identify Jumonji-D3 (JMJD3/KDM6B) histone demethylas...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD015672 | Pride
Fgf21 Autophagy Mouse Histone demethylase jmjd3 Lypolysis 
TranscriptomicsFGF21-Induced Gene Expression in Mouse Adipose Tissues
FGF21 is a novel secreted protein with robust anti-diabetic, anti-obesity, and anti-atherogenic activities in preclinical species. In the current study, we investigated the signal transduction pathways downstream of FGF21 following acute administration of the growth factor to mice. Focusing on adipo...
ORGANISM(S): Mus musculus 
2013-11-18 | E-GEOD-44095 | biostudies-arrayexpress
ProteomicsFGF21 regulates ER-stress and the Unfolded Protein Response through Sulfide Signaling
Fibroblast growth factor 21 (FGF21) is an endocrine hormone with broad metabolic actions at supraphysiological concentrations, but unclear physiological function, with recent data suggesting a link to endoplasmic reticulum (ER)-stress. ER-stress activates the unfolded protein response (UPR), a cellu...
ORGANISM(S): Homo sapiens (Human) 
2026-06-16 | PXD056693 | Pride
Apex2 Er-stress Fgf21 
ProteomicsLong-term adjustment of hepatic lipid metabolism after chronic stress and the role of FGF21
Chronic stress leads post-traumatic stress disorder (PTSD) and to metabolic complications, including fatty liver. It is feasible, that stress immediately initiates molecular mechanisms to alter energy metabolism and glucose homeostasis which interfere with hepatic lipid accumulation after stress rec...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-10 | PXD025268 | Pride
Secreted proteins Fatty liver Mouse hepatocytes Long-term effects of chronic stress 
ProteomicsFGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction
Mitochondrial integrated stress response emerged as a major adaptive pathway to respiratory chain deficiency, but tissue-specifics of its regulation or how it adapts to different levels of mitochondrial dysfunction are largely unknown. Here we report that diverse levels of mitochondrial cardiomyopat...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-27 | PXD031324 | Pride
Mitochondria Fgf21 Oxphos Cardiomyopathy Clpp 
ProteomicsHRD1-ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination
As a ubiquitin ligase, HRD1 may regulate FGF21 expression through targeting protein degradation. We then aimed to identify proteins whose expressions are altered at post-transcriptional levels in HRD1 LKO mouse liver
ORGANISM(S): Mus Musculus 
2021-12-14 | PXD030410 |
TranscriptomicsFibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice
Fibroblast growth factor 21 (Fgf21) has emerged as a potential plasma marker to diagnose non-alcoholic fatty liver disease (NAFLD). To study the molecular processes underlying the association of plasma Fgf21 with NAFLD, we explored the liver transcriptome data of a mild NAFLD model of aging C57BL/6J...
ORGANISM(S): Mus musculus 
2016-08-09 | E-GEOD-84495 | biostudies-arrayexpress
TranscriptomicsMuscle mitochondrial stress-induced metabolic adaptations do not require FGF21 action
Fibroblast growth factor 21 (FGF21) is a key metabolic regulator which was recently discovered as stress-induced myokine and common denominator of muscle mitochondrial disease. However, its precise function and pathophysiological relevance remains unknown. Here we demonstrate that white adipose tiss...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-71749 | biostudies-arrayexpress
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