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ProteomicsQuantitative histone mass spectrometry identifies elevated histone H3 lysine 27 trimethylation in melanoma
Normal cell growth is characterized by a regulated epigenetic program that drives cellular activities such as gene transcription, DNA replication and DNA damage repair. Perturbation of this epigenetic program can lead to events such as mis-regulation of gene transcription and diseases such as cancer...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079979 | MassIVE
ProteomicsQuantitative histone mass spectrometry identifies elevated histone H3 lysine 27 trimethylation in melanoma
Normal cell growth is characterized by a regulated epigenetic program that drives cellular activities such as gene transcription, DNA replication and DNA damage repair. Perturbation of this epigenetic program can lead to events such as mis-regulation of gene transcription and diseases such as cancer...
ORGANISM(S): Homo sapiens (Human) 
2015-12-02 | PXD002471 | Pride
Human Runx3 Histone h3 lysine 27 trimethylation Melanoma Ezh2 
TranscriptomicsHistone H3 lysine 27 trimethylation of miRNA genes in HMEC and HMF
Normal cell type specific histone H3 lysine 27 trimethylation of miRNA genes. HMEC and HMF represent two distinct differentiated cell type present in mammary gland each with a distinct phenotype, a distinct epigenotype as well as distinct miRNA expression pattern. The aim of the study was to determi...
ORGANISM(S): Homo sapiens 
2011-04-05 | E-GEOD-28376 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of trimethylated histone H3-K27 in human prostate cancer cell line PC3
Epigenetic silencing in cancer cells is mediated by at least two distinct histone modifications, polycomb based histone H3 lysine 27 trimethylation (H3K27triM) and H3K9 dimethylation.

Using chromatin immunoprecipitation-microarrays (ChIP-chip) in prostate cancer cells, we found that up to 5% ...
ORGANISM(S): Homo sapiens 
2008-04-26 | E-MEXP-1585 | biostudies-arrayexpress
GenomicsGlobal Mapping of Histone H3 K4 and K27 Trimethylation: Lineage Fate Determination of Differentiating CD4+ T Cells
Multipotential naïve CD4+ T cells differentiate into distinct lineages including Th1, Th2, Th17, and inducible T regulatory (iTreg) cells. The remarkable diversity of CD4+ T cells begs the question whether the observed changes reflect terminal differentiation with heritable epigenetic modifications ...
ORGANISM(S): Mus musculus 
2009-01-21 | E-GEOD-14254 | biostudies-arrayexpress
TranscriptomicsTriplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation [RNA-Seq]
Down syndrome (DS) confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (ALL), yet the mechanisms underlying this association are undefined.  We show that triplication of only 31 genes orthologous to the putative DS Critical Region (DSCR) on chr.21q22 is sufficient to promote B ce...
ORGANISM(S): Mus musculus 
2014-04-20 | E-GEOD-48553 | biostudies-arrayexpress
GenomicsHistone H3 lysine 27 trimethylation of miRNA genes in HMEC and HMF
Normal cell type specific histone H3 lysine 27 trimethylation of miRNA genes. HMEC and HMF represent two distinct differentiated cell type present in mammary gland each with a distinct phenotype, a distinct epigenotype as well as distinct miRNA expression pattern. The aim of the study was to determi...
ORGANISM(S): Homo sapiens 
2011-04-05 | GSE28376 | GEO
ProteomicsIdentification of ubiquitination sites of purified histone H3
Histones modulate gene expression by chromatin compaction, regulating numerous processes such as differentiation. However, the mechanisms underlying histone degradation remain elusive. When compared with their differentiated counterparts, immortal human embryonic stem cells (hESCs) have a unique chr...
ORGANISM(S): Homo sapiens (Human) 
2020-06-01 | PXD018621 | Pride
Epigenetics Ubiquitination Histone h3 
UnknownThe CHD3 remodeler PICKLE promotes trimethylation of histone H3 lysine 27.
Not available
S-EPMC2504882 | biostudies-literature
GenomicsHistone H3 lysine 4 and 27 trimethylation signatures associated with human Alzheimer’s disease
Histone H3 lysine 4 and 27 trimethylation signatures associated with human Alzheimer’s disease
PRJNA804862 | ENA
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