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ProteomicsHistone H3 tail interactome in MPC11 murine myeloma cells
We have used peptide capture in conjunction with super-SILAC quantification to carry out an unbiased high-throughput analysis of the composition of protein complexes that bind to histone H3K9/S10 and H3K27/S28 methyl-phospho modifications. We compared binding profiles of nuclear proteins from MPC11 ...
ORGANISM(S): Mus musculus (Mouse) 
2016-05-04 | PXD001273 | Pride
Lc-msms Histone modification Peptide capture Histone h3 tail interactome 
ProteomicsH3 N-terminal tail peptide interactome
The closely related replicative H3 and non-replicative H3.3 variants show specific requirement during development in vertebrates. Whether it involves distinct mode of deposition or unique roles once incorporated into chromatin remains unclear. To disentangle the two aspects, we took advantage of the...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2020-03-13 | PXD016497 | Pride
Xenopus laevis Development Histone variant H3.3s31 
UnknownDevelopment of nucleus-targeted histone-tail-based photoaffinity probes to profile the epigenetic interactome in native cells.
Not available
S-EPMC11704063 | biostudies-literature
ProteomicsDynamic protein interactions of the Polycomb Repressive Complex 2
Polycomb proteins assemble to form complexes with important roles in epigenetic regulation. The Polycomb Repressive Complex 2 (PRC2) modulates the di- and tri-methylation of lysine 27 on histone H3, each of which are associated with gene repression. Although three subunits, EZH1/2, SUZ12 and EED, fo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080739 | MassIVE
UnknownIdentification of protein complexes that bind to histone H3 combinatorial modifications using super-SILAC and weighted correlation network analysis.
Not available
S-EPMC4330348 | biostudies-literature
TranscriptomicsHNRNPU RNA targets and DNA methylation changes during neural differentiation
This study investigates the molecular mechanisms by which the DNA/RNA-binding protein HNRNPU regulates gene expression during early human neural development. Pathogenic variants in HNRNPU cause a severe neurodevelopmental disorder, but the underlying mechanisms remain poorly understood. To explore t...
ORGANISM(S): Homo sapiens 
2026-02-02 | E-MTAB-14910 | biostudies-arrayexpress
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