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ProteomicsComparative analysis of differential cellular genome and proteome regulation by HIV-1 and HIV-2 pseudovirions in the early phase of infection
Beside the similar structure and genomic organization of human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2), striking difference exist between the in terms of replication dynamics and clinical manifestation of infection. Although pathomechanism of HIV-1 infection well characterized, relat...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Human Immunodeficiency Virus 2 (ncbitaxon:11709) Human Immunodeficiency Virus 1 (ncbitaxon:11676) 
2023-08-03 | MSV000092581 | MassIVE
ProteomicsCellular proteomic changes in the immediate early phase of HIV-1 and 2 transduction
Human immunodeficiency viruses type 1 and 2 (HIV-1 and 2) are known to depend on cellular host machinery for their replication and survival. While most of the studies on cellular proteomic and transcriptomic changes focused on the late-phase of the infection, studies of those changes in the early ti...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD024243 | Pride
Hiv-1 Cellular proteome change Hiv-2 
ProteomicsBlood plasma from people living with HIV-1 or HIV-2
In this study we performed data-independet mass-spectrometry analysis of blood plasma collected from a cohort consisting of people living with HIV-1, people living with HIV-2, and HIV seronegative individuals. The data was used to infer signs of damage to a wide array of tissues and cell types.
ORGANISM(S): Homo sapiens (Human) Human immunodeficiency virus 2 Human immunodeficiency virus 1 
2024-02-16 | PXD045155 | Pride
Human Blood plasma Hiv-1 Hiv-2 
ProteomicsPHD3-mediated HIV-2 Vpx peptide hydroxylation
This dataset contains comparative mass spectrometry analysis investigating proline hydroxylation of synthetic HIV-2 Vpx peptides under two conditions: with and without PHD3 enzyme treatment. The analysis was performed using a high-resolution mass spectrometer coupled to a nano-LC system. The dataset...
ORGANISM(S): Human Immunodeficiency Virus 2 
2025-04-03 | PXD059242 | JPOST Repository
ProteomicsHIV/SARS-CoV-2 co-infection mediated proteomic changes in CNS potentiate neuro-HIV
Coronavirus disease 2019 (COVID-19) survivors frequently experience a wide range of symptoms known as post-acute sequelae of SARS-CoV-2 (PASC) or long COVID. Importantly, complications arising from microvascular dysfunction, blood-brain barrier (BBB) disruption, and chronic neuroinflammation have be...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD043206 | Pride
ProteomicsCross-linking MS analysis of HIV-2 Vpx-PHD3 protein interaction
This dataset presents chemical crosslinking mass spectrometry (CL-MS) analysis of protein-protein interactions between HIV-2 Vpx and PHD3. The experimental data includes MS spectra obtained from protein complexes comprising recombinant Vpx and PHD3 crosslinked using DSBU under physiological conditio...
ORGANISM(S): Human Immunodeficiency Virus 2 
2025-04-03 | PXD059241 | JPOST Repository
TranscriptomicsInduction of IL-17+ T-cells by HIV-Tat protein is mediated via Vascular Endothelial Growth Factor Receptor-2
Anti-retroviral therapy (ART) has transformed human immunodeficiency virus (HIV) infection from a fatal illness to a chronic condition by controlling viral replication and restoring immune function. However, chronic T-cell activation can be observed in 20-35% of individuals on ART, resulting in an i...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-44460 | biostudies-arrayexpress
ProteomicsDifferent expressed proteins of HIV-infected long-term non-progressors (LTNPs) and regular progressors (RPs)
The whole blood samples were obtained from 3 LTNPs and 2 RPs HIV-1 infected patients, and the CD4+ T cells were isolated using anti-CD4-specific antibody-coated microbeads (130-045-101, Miltenyi Biotec, Germany) according to the manufacturer's instructions. Then the proteins extracted from the CD4+ ...
ORGANISM(S): Homo Sapiens 
PXD046078 |
GenomicsHIV-2 evolved ZAP resistance despite increased CpG levels
HIV-2 evolved ZAP resistance despite increased CpG levels
PRJNA1228977 | ENA
UnknownComparison of the Antiviral Activity of Bictegravir against HIV-1 and HIV-2 Isolates and Integrase Inhibitor-Resistant HIV-2 Mutants.
Not available
S-EPMC6496081 | biostudies-literature
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