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MetabolomicsExometabolomics of HK2, 786-O cells cultured in Plasmax media
Not available
ORGANISM(S): Homo sapiens 
ST002226 | MetabolomicsWorkbench
MetabolomicsCatabolism of branched-chain amino acids (BCAAs) in renal cells HK2 and 786-O
Not available
ORGANISM(S): Homo sapiens 
ST002220 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of human mono or co-cultured HMEC-1 and HK-2 cells to identify the influence of microvascular endothelial cells on transcriptional regulation of proximal tubular epithelial cells
The effect of the presence of HMEC-1 cells on HK-2 cell gene expression was investigated. Cells were cultured in mono or co-culture on opposite sides of aluminium oxide filters, 0.2 ?µM pore size. These conditions provide a close proximity but not direct contact. RNA from HK-2 cells was assayed with...
ORGANISM(S): Homo sapiens 
2008-02-05 | E-MEXP-1178 | biostudies-arrayexpress
ProteomicsTime-series proteomic study of diabetic nephropathy in human proximal tubular epithelial HK-2 cells
Shotgun time-series proteomic analysis based on stable isotope dimethyl labeling and UHPLC-MS/MSC to relatively quantify the changes in protein expression of human proximal tubular HK-2 cells exposed to a diabetic-like microenvironment
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD015102 | Pride
Proximal tubular cells Proteomics Hypoxia Hyperglycemia Diabetic nephropathy Hk-2 cells 
TranscriptomicsRNAseq of HK-2 human kidney tubular cells knock-out for CNDP2
The renal proximal tubular cell line HK-2 was subjected to CRISPR-CAS9 mediated CNDP2 gene deletion.
ORGANISM(S): Homo sapiens 
2024-07-19 | E-MTAB-11436 | biostudies-arrayexpress
MetabolomicsBranched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming

Macrophages are prominent immune cells in the tumor microenvironment that can be educated into pro-tumoral phenotype by tumor cells to favor tumor growth and metastasis. The mechanisms that mediate a mutualistic relationship between tumor cells and macrophages remain poorly characterized. Here, w...

2022-10-03 | MTBLS4497 | MetaboLights
TranscriptomicsSUDHL-4 cells: suspension vs. co-cultured with HK cells
We first performed miRNA analysis on SU-4 cells in suspension, and after 24 and 48 h of HK co-culture. To ensure that no HK cell contamination occurred, SU-4 cells in suspension and after co-culture were purified by CD19-positive magnetic selection, followed by total RNA isolation. Two-condition exp...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-49253 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of HK-2 cells treated with cisplatin
Chemotherapeutic use of cisplatin is limited by its severe side effects. In this study, we demonstrated that cisplatin induces cell death in a proximal tubular cell line by suppressing glycolysis- and tricarboxylic acid (TCA)/mitochondria-related genes. HK-2 cells were cultured to confluence in 100m...
ORGANISM(S): Homo sapiens 
2015-06-09 | E-GEOD-69644 | biostudies-arrayexpress
GenomicsFAM134B deficiency in HK-2 cells
FAM134B deficiency in HK-2 cells
PRJNA1141991 | ENA
TranscriptomicsStress-related gene expression of HK-2 cells exposed to GF/FAF HSA, GF HSA, AngII or AngII+Cand
Proteinuria is pathogenic to proximal tubular cells (PTC) and linked with progression to renal failure. Angiotensin II (AngII) is also independently involved in the pathogenesis of progressive renal injury in varied kidney disease. The effects of human serum albumin (HSA) overload, AngII and candesa...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-10648 | biostudies-arrayexpress
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