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ProteomicsHLA B-27 rats peptidome - The HLA-B27 peptidome in vivo in spondyloarthritis-susceptible HLA-B27 transgenic rats and the effect of ERAP1 deletion
HLA-B27 is a class I major histocompatibility (MHC-I) allele that confers susceptibility to the rheumatic disease ankylosing spondylitis (AS) by an unknown mechanism. ERAP1 is an aminopeptidase that trims peptides in the endoplasmic reticulum for binding to MHC-I molecules. ERAP1 shows genetic epist...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-02-13 | PXD005502 | Pride
Transgenic rats Hla-b27 Peptidome Ankylosing spondylitis Human leukocytes antigen 
ProteomicsHLA-B27 interferes with TGF-/activin signaling in Drosophila and rat transgenic models, resulting in pathogenic consequences relevant for spondyloarthritis.
Background The striking association of HLA-B27 with spondyloarthritis (SpA) has been known for 50 years. However, its pathophysiological significance remains incompletely understood. In the HLA-B27/human-β2 microglobulin (hβ2m) transgenic rat (B27 rat) that spontaneously develops inflammatory pheno...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2024-10-17 | PXD047119 | Pride
Hla peptidome Spondyloarthritis  bmp/tgfβ pathway  hla-b27  cd4+ t cells  rat  drosophila 
ProteomicsIdentification of MHC ligands through allele guided isolation combined with machine learning for specific MHC assignment
Isolation of MHC ligands and subsequent analysis by mass spectrometry is considered the gold standard for defining targets for T cell-based immunotherapies. However, as many targets of high tumor-specificity are only presented at low abundance on the cell surface of tumor cells, the efficient isolat...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD061101 | Pride
Hla assignment Machine learning Immunopeptidome 
ProteomicsHLA-DR MAPPs Assay in moDCs From 8 Donors Loaded With Infliximab
MHC-associated peptide proteomics (MAPPs) enables direct identification of peptides naturally processed and presented by APCs, providing experimental evidence for antigen processing and HLA class II presentation. In this dataset published in PMID: 41085630, an HLA-DR–focused MAPPs workflow was used ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD074155 | Pride
ProteomicsAllotype-specific glycosylation and cellular localization of HLA class I proteins
Presentation of self- and foreign peptide antigens by human leukocyte antigen (HLA) complexes at the cell surface is a key process in our immune response. The alpha-chain, the part of the HLA class I complex that contains the peptide binding groove, is one of the most polymorphic proteins in the hum...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD023684 | Pride
Glycoproteomics Mhc Hla 
TranscriptomicsTranscription profiling of bone marrow samples of 31 children with acute lymphoblastic leukemia to identify changes in gene expression that are associated with the current risk assignment, irrespective of the genetic subtype
We analyzed bone marrow samples of 31 children with acute lymphoblastic leukemia to identify changes in gene expression that are associated with the current risk assignment, irrespective of the genetic subtype
ORGANISM(S): Homo sapiens 
2004-06-28 | E-MEXP-120 | biostudies-arrayexpress
Genomics
Novel HLA allele discovery
PRJEB125710 | ENA
UnknownAssessment of HLA-B genetic variation with an HLA-B leader tool and implications in clinical transplantation.
Not available
S-EPMC8753210 | biostudies-literature
UnknownCost-efficient multiplex PCR for routine genotyping of up to nine classical HLA loci in a single analytical run of multiple samples by next generation sequencing.
Not available
S-EPMC4404632 | biostudies-literature
UnknownResolving unknown nucleotides in the IPD-IMGT/HLA database by extended and full-length sequencing of HLA class I and II alleles.
Not available
S-EPMC10944811 | biostudies-literature
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