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TranscriptomicsTranscription profiling of human dormant and angiogenic breast cancer, osteosarcoma, liposarcoma and brain tumor cell lines
The Goal of this study is to explore the transcriptional differences between angiogenic and non-angiogenic tumors generated in Dr. Folkman's Lab, Harvard Medical School.
Referneces:
Almog N, Henke V, Flores L, Hlatky L, Kung AL, Wright RD, Berger R, Hutchinson L, Naumov GN, Bender E, Akslen LA...
ORGANISM(S): Homo sapiens 
2009-02-03 | E-TABM-390 | biostudies-arrayexpress
TranscriptomicsProton irradiation augments the reduction in tumor progression observed with advanced age
Proton irradiation is touted for its improved tumor targeting due to the physical advantages of ion beams for radiotherapy. Recent studies from our laboratory have shown that, in addition to targeting advantages, proton irradiation can inhibit angiogenic and immune factors and thereby modulate tumor...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-45609 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human dermal endothelial cells treated with 10ng/ml VEGF and 20ng/ml basic Fibroblast Growth Factor (bFGF) for 6h
Cells were treated with 10ng/ml VEGF and 20ng/ml basic Fibroblast Growth Factor (bFGF) for 6h at 37°C with 5 % CO2 and 95 % humidity..
ORGANISM(S): Homo sapiens 
2007-04-25 | E-RZPD-14 | biostudies-arrayexpress
TranscriptomicsAge and Space Irradiation Modulate Tumor Progression: Implications for Carcinogenesis Risk
Age plays a major role in tumor incidence and is an important consideration when modeling the carcinogenesis process or estimating cancer risks. Epidemiological data show that from adolescence through middle age, cancer incidence increases with age. This effect is commonly attributed to a lifetime a...
ORGANISM(S): Mus musculus 
2013-06-13 | E-GEOD-45606 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal pancreas samples, and samples from patients with chronic pancreatitis, pancreatic cancer and metastatic pancreatic cancer
This dataset presents the gene expression profiles of 36 frozen pancreas samples. RNA from 9 normal pancreas samples, 9 samples from patients with chronic pancreatitis, 9 samples from patients with pancreatic cancer and 9 samples from patients with metastatic pancreatic cancer was extracted and hybr...
ORGANISM(S): Homo sapiens 
2006-10-10 | E-EMBL-6 | biostudies-arrayexpress
TranscriptomicsProton Irradiation Impacts Age Driven Modulations of Cancer Progression Influenced by Immune System Transcriptome Modifications from Splenic Tissue
Age plays a crucial role in the interplay between tumor and host; with further perturbations induced by irradiation. Proton irradiation on tumors induces biological modulations including inhibition of angiogenic and immune factors critical to “hallmark” processes impacting tumor development, in addi...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-67243 | biostudies-arrayexpress
TranscriptomicsHost Age is a Systemic Regulator of Gene Expression Impacting Cancer Progression
Given that aging is the major determinant of cancer incidence, and that cancer incidence is dictated in large part by processes modulating progression of existing subclinical cancers, we demonstrate that aging may be an organizing axis for identifying cancer progression-modulating processes. This wo...
ORGANISM(S): Mus musculus 
2015-03-03 | E-GEOD-66414 | biostudies-arrayexpress
TranscriptomicsMYC and CHK1 Dependent Cell Death in T-cell Lymphoma and Hodgkin Lymphoma Cell Lines and Human Xenograft Models Via Anti-Proteasomal Therapy (Affymetrix)
We examined the biological effects of a potent second-generation proteasome inhibitor, ixazomib, in T-cell lymphoma and Hodgkin lymphoma cell lines and human xenograft models. Ixazomib resulted in time- and dose-dependent cytotoxicity and apoptosis in all cell lines (IC50’s <75nM). In vivo studies v...
ORGANISM(S): Homo sapiens 
2015-06-08 | E-GEOD-66417 | biostudies-arrayexpress
TranscriptomicsMYC and CHK1 Dependent Cell Death in T-cell Lymphoma and Hodgkin Lymphoma Cell Lines and Human Xenograft Models Via Anti-Proteasomal Therapy (Illumina)
We examined the biological effects of a potent second-generation proteasome inhibitor, ixazomib, in T-cell lymphoma and Hodgkin lymphoma cell lines and human xenograft models. Ixazomib resulted in time- and dose-dependent cytotoxicity and apoptosis in all cell lines (IC50’s <75nM). In vivo studies v...
ORGANISM(S): Homo sapiens 
2015-06-08 | E-GEOD-66415 | biostudies-arrayexpress
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