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ProteomicsYTHDC1 functions as a molecular chaperone to suppress ALS-Linked hnRNPA1 mutants from aggregation
Proteostasis failure underlies many neurodegenerative disorders (NDs), yet ATP-independent chaperone mechanisms in NDs remain incompletely defined. Here, we identify the N6-methyladenosine (m6A) binding protein YTHDC1 as an ATP-independent molecular chaperone whose activity is mediated by a highly a...
ORGANISM(S): Homo sapiens (Human) 
2026-08-22 | PXD073870 | Pride
Phosphoproteomics Ythdc1 Hnrnpa1 Hek293t Sy5y Lc-ms/ms 
GenomicsCLIP-seq analysis of hnRNPA1-RNA interactions
CLIP-seq analysis of hnRNPA1-RNA interactions
PRJNA998366 | ENA
ProteomicsEpigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity
Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity, PPI of ZMYND11 in LNCap
ORGANISM(S): Homo Sapiens 
2024-08-28 | PXD055421 |
GenomicsRNA sequencing of hnRNPA1 knockdown in HeLa cells
RNA sequencing of hnRNPA1 knockdown in HeLa cells
PRJNA1109337 | ENA
ProteomicsEpigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity
Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity, To investigate the function of ZMYND11 in prostate cancer, We performed Co-IP and mass-spectometry (MS) analysis of ZMYND11.
ORGANISM(S): Homo Sapiens 
2024-08-27 | PXD055219 |
GenomicsHnrnpa1 is essential for early zebrafish development and lipid metabolism
Hnrnpa1 is essential for early zebrafish development and lipid metabolism
PRJNA1451112 | ENA
OtherCLIP-seq analysis of hnRNPA1-RNA interactions
hnRNPA1 CLIP-seq experiments were conducted on HEK293T cells transiently expressing WT hnRNPA1 and hnRNPA1-DSB mutant
ORGANISM(S): Homo sapiens 
2023-12-31 | GSE238202 | GEO
Genomics
HNRNPA1 RIP-sequence
PRJNA721393 | ENA
Genomics
HNRNPA1 OE RNA-sequence
PRJNA721369 | ENA
TranscriptomicsRNA sequencing of hnRNPA1 knockdown in HeLa cells
shRNA knockdown against hnRNPA1 in HeLa cells followed by RNA-seq.
ORGANISM(S): Homo sapiens 
2026-01-12 | GSE267007 | GEO
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